Respiratory Drugs Flashcards
Upper respiratory tract consists of
Nares, nasal cavity, pharynx, and larynx
Lower respiratory tract consist of
Trachea, bronchi, bronchioles, alveoli, and alveolar-capillary membrane
Is the movement of air from the atmosphere through the upper and lower aiways to the alveoli
Ventilation
Is the process whereby gas exhange occurs at the alveolar-capillary membrane
Respiration
Phases pf respiration
- Ventilation
- Perfusion
- Diffusion
Movement of molecules from higher to lower concentrations, take place when oxygen passes into the capillary bed to be circulated and carbon dioxide leaves the capillary bed and difuses into the alveli
Diffusion
Is the lung volume based on the pressure in the alveoli. This volume determines the lung’s ability to stretch.
Lung compliance
Factors that affect lung compliance
- Connective tissue
- Surface tension in the alveoli, which is controlled by surfactant
Compete with histamine for receptor sites and prevent a histamine response
Antihistamines
Cause drowsiness, dry mouth and other anicholinergic symtpoms, and decrease nasal itching and tickling that cause sneezing
First generation antihistamines
Blocks the effects of histamine by compteting for and occupying H1 receptor sites. Sometimes used in sleep-aid products
First genneration Antihistamines: Dipenhydramine
Nonsedating antihistamines that causes fewer anticholinergic symptoms.
Second generation antihistamines: cetirizine, fexofenadine, loratadine, and azelastine
Stimulates the alpha-adrenergic receptors, producing vasoconstriction of the capillaries within the nasal mucosa.
Nasal decongestants
Also known as alpha-adrenergic agonists. Use primarily for allergic rhinitis, including hay fever and profuse nasal discharge
Systemic Decongestants: ephedrine, phenylephrine, pseudoephedrine
Effective for treating allergic rhinitis because they have an anti-inflammatory action, thus decreasing the allergic rhinitis symptoms of rhinorrhea, sneezing, and congestion.
Intranasal Glucocorticoids