ANTIULCER DRUGS Flashcards
Is a circumcised lesion that develops in the mucous membranes of the lower esophagus, stomavh duodenum, or jejunum.
Peptic ulcers
Are aimed at either eradicating H.pylori or restoring the balance between acid and pepsin secretions and the GI mucosal defense.
Peptic Ulcer Drugs
Is a gram-negative bacterium that is thought to be a major causative factor in the formation of peptic ulcers and gastritis.
Helicobacter pylori or H.pylori
Classification of Antiulcer drugs:
- Systemic antibiotics
- Antacids
- H2 receptor antagonists
- Proton Pump inhibitors
- Other peptic ulcer drugs, such as misoprostol and sucralfate
Systemic anitbiotics used to treat H.pylori include:
*amoxicillin
*clarithromycin
*metronidazole
*tetracycline
Decreases the absorption of tetracycline
Dairy products
Successful treatment involves the use of
Two or more antibiotics in comibination with other drugs such as acid suppressants
Increases digoxin levels
Tetracycline
Can cause a severe reaction when combined with alcohol
Metronidazole
increase the risk of bleeding when taken with or anticoagulants
Metronidazole and tetracycline
Work locally in the stomach by neutralizing gastric acid.
Antacids
Antacid medications include:
*aluminum carbonate gel
*calcium carbonate
*magaldrate (aluminum-magnesium complex)
*magnesium hydroxide and aluminum hydroxide
*simethicone
Block histamine from stimulating the acid secreting arietal cells of the stomach
H2-receptor antagonists
These are the commonly H2-receptor anagonista drugs:
*cimetidine
*famotidine
*nizatidine
*ranitidine
Disrupt chemical binding in stomach cells to reduce acid production, lessening irritation and allowing peptic ulcers to better heal
Proton-pump inhibitors
