Pharmacokinetic Flashcards
It is the process of drug movement to achieve drug action
Pharmacokinetics
Movement of drug practicles from the gastrointestinal to bodily fluids.
Absorption
Parts of absorption:
*passive
*active
*Pinocytosis
Occurs mostly by fusion ( from higher to lower concentration)
Passive
Requires carriers such as enzyme or protein to move drug against a concentration gradient, energy is required.
Active
Cells carry a drug across their membrane by engulfing drug particles.
Pinocytosis
Factors affecting drug absorption:
*bloodflow
*pain, stress, & food
*exercise
*medicational route
It is subcategory of absorption. The percentage of administered drug dose that reaches the systemic circulation.
Bioavailability
Drug passes to liver first and suffers extensive biotransformation.
First-pass effect/hepatic first pass
Rapid absorption results to
Increase in bioavailability
Is the process that drug becomes available to the body through drug passing from the bloodstream to body tissues and organs
Distribution
Semipremeable membrane in CNS to protect brain from foreign substances
Blood Brain Barrier
The process by which body inactivates or biotransforms drugs.
Metabolism/biotransformation
Primary site of metabolism
Liver
Time it takes for one-half of the drug concentration to be eliminated.
Half-life of a drug
