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PHARMACOLOGY > ANALGESIA > Flashcards

ANALGESIA Flashcards

1
Q

Endophorin

A

mu

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2
Q

Dynophorin

A

Kappa

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3
Q

Enkephalin

A

Delta

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4
Q

Nociceptin

A

Orphan FQ receptor

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5
Q

If morphin is given orally

A

Absorption is slow as morphine undergoes extensive first pass metabolism

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6
Q

Morphine adverse effects:

A
  1. Nausea
  2. Vomiting
  3. Dizziness
  4. Mental Clouding
  5. Respiratory depression
  6. Urinary retention
  7. Hypotension
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7
Q

Withdrawal symptoms of sudden cessation of opioids:

A
  1. Drug seeking behavior
  2. Yawning
  3. Lacrimation
  4. Sweating
  5. Restlessness
  6. Mydriasis
  7. Tremors
  8. Nausea
  9. Tachycardia
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8
Q

1 mg of methadone is substituded to

A

4 mg of morphine

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9
Q

Methadone is gradually reduced and stopped within

A

10 days

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10
Q

1/10th as potent as morphine.

A

Pethidine

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11
Q

Less spasmodic action in smooth muscles

A

Pethidine

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12
Q

Pethidine has rapid and short duration of action

A

2-3 hours

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13
Q

Hass vagolytic effect and less histamine release safer for asthmatics

A

Pethidine

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14
Q

100x more potent than morphine

A

Fentanyl

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15
Q

Higly lipid soluble and fast acting

A

Fentanyl

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16
Q

Increases intracranial pressure

A

Fentanyl

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17
Q

Fentanyl is combine with what to produce neuroleptanalgesia

A

Droperidol

18
Q

Synthetic centrally acting analgesia indicated to moderate and moderately severe pain

A

Tramadol

19
Q

Used in the treatment of labor and cancer pain

A

Tramadol

20
Q

Inhibits reuptake of serotonin and noreinephrine

A

Tramadol

21
Q

Competitive against of all tyes of opioid receptors

A

Naloxone

22
Q

Blocks u-receptors at much lower dosr

A

Naloxone

23
Q

Naloxone is always injected at IV of

A

0.4 to 0.8 mg

24
Q

Analgesics adverse effects:

A
  1. Epigastric distress
  2. Photosensitivity
  3. Haemolysis
  4. Nephrotoxicity
  5. Reye’s syndrome
    6 . Salicylism
  6. Acute salicylate intoxication
25
Q

Salicylates are metabolised in the liver by

A

Glycine and glucoronide conjugation

26
Q

What should the analgesic dose be

A

600 mg 3x a day

27
Q

Analgesia contraindications:

A
  1. Petic ulcer patients
  2. bleeding disorder
  3. Chronic liver disease
  4. Pregnancy
28
Q

It raises pain threshold

A

Paracetamol

29
Q

Has Weak peripheral anti-inflammatory component

A

Paracetamol

30
Q

Has poor ability to inhibit COX in the presence of peroxide

A

Paracetamol

31
Q

One of the best drug to be used as antipyretic

A

Paracetamol

32
Q

Paracetamol dose

A

500-1000 mg TDS

33
Q

Better tolerated alternative to pain

A

Ibuprofen

34
Q

Ibuprofen is contraindicated to

A

Petic ulcer and pregnancy

35
Q

Selectively COX-2 inhibitor

A

Nemuslides

36
Q

Primarily for short lasting painful inflammatory like sports injuries and sinusitis

A

Nemuslides

37
Q

Dose of nemuslides

A

100 mg daily

38
Q

NSAIDS for mile to moderate pain with little inflammation

A

Paracetamol or low dose ibuprofen

39
Q

NSAIDS for acute muscoskeletal/injury associated inflammation

A

Diclofenac and ibuprofen

40
Q

Exacerbation of acute pain-high dose

A

Aspirin and indomethacin

41
Q

NSAIDS for severe pain

A

Asiprin or combination with narcotic drug

PHARMACOLOGY (13 decks)

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