ANALGESIA

Question 1

Endophorin

Answer 1

mu

Question 2

Dynophorin

Answer 2

Kappa

Question 3

Enkephalin

Answer 3

Delta

Question 4

Nociceptin

Answer 4

Orphan FQ receptor

Question 5

If morphin is given orally

Answer 5

Absorption is slow as morphine undergoes extensive first pass metabolism

Question 6

Morphine adverse effects:

Answer 6

1. Nausea
2. Vomiting
3. Dizziness
4. Mental Clouding
5. Respiratory depression
6. Urinary retention
7. Hypotension

Question 7

Withdrawal symptoms of sudden cessation of opioids:

Answer 7

1. Drug seeking behavior
2. Yawning
3. Lacrimation
4. Sweating
5. Restlessness
6. Mydriasis
7. Tremors
8. Nausea
9. Tachycardia

Question 8

1 mg of methadone is substituded to

Answer 8

4 mg of morphine

Question 9

Methadone is gradually reduced and stopped within

Answer 9

10 days

Question 10

1/10th as potent as morphine.

Answer 10

Pethidine

Question 11

Less spasmodic action in smooth muscles

Answer 11

Pethidine

Question 12

Pethidine has rapid and short duration of action

Answer 12

2-3 hours

Question 13

Hass vagolytic effect and less histamine release safer for asthmatics

Answer 13

Pethidine

Question 14

100x more potent than morphine

Answer 14

Fentanyl

Question 15

Higly lipid soluble and fast acting

Answer 15

Fentanyl

Question 16

Increases intracranial pressure

Answer 16

Fentanyl

Question 17

Fentanyl is combine with what to produce neuroleptanalgesia

Answer 17

Droperidol

Question 18

Synthetic centrally acting analgesia indicated to moderate and moderately severe pain

Answer 18

Tramadol

Question 19

Used in the treatment of labor and cancer pain

Answer 19

Tramadol

Question 20

Inhibits reuptake of serotonin and noreinephrine

Answer 20

Tramadol

Question 21

Competitive against of all tyes of opioid receptors

Answer 21

Naloxone

Question 22

Blocks u-receptors at much lower dosr

Answer 22

Naloxone

Question 23

Naloxone is always injected at IV of

Answer 23

0.4 to 0.8 mg

Question 24

Analgesics adverse effects:

Answer 24

1. Epigastric distress
2. Photosensitivity
3. Haemolysis
4. Nephrotoxicity
5. Reye’s syndrome
   6 . Salicylism
6. Acute salicylate intoxication

Question 25

Salicylates are metabolised in the liver by

Answer 25

Glycine and glucoronide conjugation

Question 26

What should the analgesic dose be

Answer 26

600 mg 3x a day

Question 27

Analgesia contraindications:

Answer 27

1. Petic ulcer patients 2. bleeding disorder 3. Chronic liver disease 4. Pregnancy

Question 28

It raises pain threshold

Answer 28

Paracetamol

Question 29

Has Weak peripheral anti-inflammatory component

Answer 29

Paracetamol

Question 30

Has poor ability to inhibit COX in the presence of peroxide

Answer 30

Paracetamol

Question 31

One of the best drug to be used as antipyretic

Answer 31

Paracetamol

Question 32

Paracetamol dose

Answer 32

500-1000 mg TDS

Question 33

Better tolerated alternative to pain

Answer 33

Ibuprofen

Question 34

Ibuprofen is contraindicated to

Answer 34

Petic ulcer and pregnancy

Question 35

Selectively COX-2 inhibitor

Answer 35

Nemuslides

Question 36

Primarily for short lasting painful inflammatory like sports injuries and sinusitis

Answer 36

Nemuslides

Question 37

Dose of nemuslides

Answer 37

100 mg daily

Question 38

NSAIDS for mile to moderate pain with little inflammation

Answer 38

Paracetamol or low dose ibuprofen

Question 39

NSAIDS for acute muscoskeletal/injury associated inflammation

Answer 39

Diclofenac and ibuprofen

Question 40

Exacerbation of acute pain-high dose

Answer 40

Aspirin and indomethacin

Question 41

NSAIDS for severe pain

Answer 41

Asiprin or combination with narcotic drug