Respiratory Acidosis - EXAM 3 Flashcards
Normal pH
7.35-7.45
Normal PaCO2
35-45
Normal HCO3 (bicarbonate)
24-30
Normal PaO2
75-100
Hypoxemic Respiratory Failure
- Inadequate transfer between alveoli and pulmonary capillary beds
- PaO2 less than or equal to 60 mm Hg on 60% O2
Room air oxygen level
21%
Hypercapnic Respiratory Failure
- Most common ABG abnormality
- Insufficient CO2 removal
- PaCO2 greater than 45 mm Hg
- pH less than 7.35
Causes of Hypoxemic Respiratory Failure
- Intrapulmonary shunting
- Pneumonia
- Smoke inhalation
- Shock
- ARDS
- V-Q mismatch
- PE
Intrapulmonary shunting
Blood exits lung without participating in gas exchange
- Pnrumonis secretions
- Mucus Plug
- Blood clot from PE
- ARDS: Acute Respiratory Distress Syndrome
Hypercapnic Respiratory Failure
- Obstructive airway diseases (asthma, COPD, difficulty getting air out)
- CNS impairment
- Chest wall dysfunction (problems getting air in)
- Neuromuscular dysfunction
- Narcotics, sedatives, barbiturates
What is the respiratory compensatory component?
carbonic acid
What is the renal compensatory component?
bicarb
Respiratory center
In brain. Detects lungs to increase or decrease RR and depth in a response to the amount of CO2. CO2 is retained or blown off.
How fast does compensation occur?
System is extremely sensitive to changes in pH and compensation begins in seconds to minutes
Renal Regulation of Acid Base Balance
- Control buffer NaHCO3 (sodium bicarb)
- Takes several hours to days to kick in
- Can control HCO3 (bicarb) by either reabsorbing or excreting H+ ions