Respiratory

Question 1

mechanism of action of cromolyn sodium

Answer 1

directly binds to mast cells thereby preventing their degredation and release of histamine and leukotrienes

Question 2

mechanism of theophylline

Answer 2

inhibits phosphodiesterase. This leads to an increase of cAMP, which causes bronchodilation.

Question 3

mechanism of ipratropium bromide

Answer 3

competitive inhibition of muscarinic receptors on airway smooth muscle (M3 type)

Question 4

mechnism of steroids

Answer 4

inhibits phospholipase A2 synthesis which decrease production of arachidonic acid and its metabolites (cytokines) = decreased inflammation

inactivates NF-kB, transcription factor that produces TNFa

Question 5

what type of drug is ipratropium

Answer 5

muscarinic antagonist

Question 6

mechanism of action of omalizumab

Answer 6

anti-IgE monoclonal Ab
binds to unbound serum IgE blocking the binding to FeRI

Question 7

mechanism of action of mepolizumab/resilzumab/benralizumab

Answer 7

anti-IL 5 monoclonal therapy
prevents eosinophil differentiation, maturation, activation and survival mediated by IL-5

Question 8

zileuton mode of action

Answer 8

inhibits production of leukotriens by blocking 5-lipoxygenase preventing conversion of arachidonic acid to leukotrienes

Question 9

side effect of zileuton

Answer 9

hepatotoxic

Question 10

inhibition of myosin light chain kinase

Answer 10

LABA

Question 11

does salbutamol increase or decrease protein kinase A

Answer 11

increases protein kinase A
increases cAMP which increases PKA = bronchial smooth muscle dilatation