MSK Flashcards
Action of acetominophen
Reversibly inhibits cyclooxygenase
Action of aspirin
Irreversibly inhibits COX 1&2
Action of NSAID
Reversibly inhibits COX1&2
Action of celecoxib
Reversibly and selectively inhibits COX 2
Action of lefunamide
Reversibly inhibits dihydrooate dehydrogenase preventing pyramidine synthesis
Reduced T cell formation
Action of bisphosphonates
Bind hydroxapetite in bone inhibiting osteoclast activity and promoting osteoclasts apoptosis
Action of teriparatide
Recombinant PTH anlogue increasing osteoblast activity
action of allopurinol
Xanthinr oxidase inhibitor which decreases the conversion of hydroxanthine and xanthine to uric acid
Action of pegloticase
Recombinant uricase catalyzing uric acid to allantoin
Action of febuxostate
Inhibits xanthine oxidase
Action of probenacid
Reduced reasborption of uric acid in proximal convoluted tubule
Action of colchicine
Prevents microtubular polymerization
Action of etanercept
Fusion protein (decoy receptor to TNF)
“it intercepts TNf”
Action of inflixamab
Anti TNF monoclonal antibody
side effects of leflunamide
interstitial lung disease
liver impairment
hypertension
side effects of hydroxychloroquine
retinopathy
corneal deposits
pulmonary hypertension
side effects of methotrexate
pnuemonitis
myelosuppression
liver cirrhosis
side effects of etanercept
reactivation of TB
demyelination
side effects of gold
proteinuria
side effects of penicillamine
proteinuria
reactivation of myaesthenia gravis
DMARD’s that act on the S phase of the cell cycle
methotrexate
6-mercaptopurine
hydroxyurea
5-florouracil
bleomyicn acts on what phase of the cell cycle
G2 phase
chaemo drugs that act on mitosis phase (M phase) of cell cycle
vincristine
vinblastine
paclitaxel
treatment for malignant hyperthermia and its action
dantrolene
inhibits Ca release from sarcoplasmic reticulum
