Respiration - Weeks 1 to 4 Flashcards

1
Q

What is the function of the respiratory system?

A

To ensure that tissues are supplied with adequate O2
To remove CO2 from the lungs produced in metabolism
It does this via gas exchange and blood transport

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2
Q

What is tidal volume?

A

The volume which is taken in in one breath at rest (quiet respiration)

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3
Q

Define ventilation

A

The mechanical system which allow to lunds to expand and supply air to the lungs

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4
Q

Define the inspiratory reserve volume

A

The extra air breathed in, when we breathe deeper at rest

The opposite of the expiratory reserve volume

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5
Q

What creates pressure exerted by gases?

A

Gas molecules move about and collide, the more frequent or harder the collision, the more pressure a gas can exert

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6
Q

What is partial pressure?

A

The pressure exerted by a single gas in a mixture. Usually is equal to its percentage in the mixture.
Gases diffuse down partial pressure gradients

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7
Q

Boyle’s Law?

A

States that pressure is inversely proportional to volume
If constant temperature and constant amount of gas
As more collisions if higher volume in same space

Is a measure for O2 availability

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8
Q

How does Boyle’s Law apply to respiration?

A

As in inspiration, we are making the lung volume bigger which decreases the pressure in the lungs, so air flows into the lungs (as lower pressure to outside air)

Also, at altitude, air is at a lower pressure so the molecules are further away, so the amount of O2 received in one breath is lower at higher altitude.

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9
Q

Charles’ Law?

A

States that gases have more energy at higher temperatures, which increases pressure, due to more collisions
Pressure is proportional to Temperature

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10
Q

How do gases interact with fluid?

A

Dynamic- water can evaporate and gases can dissolve

Water exerts vapour pressure (saturated vapour pressure) when at equilibrium and at a constant temperature

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11
Q

Why is saturated vapour pressure important in respiration?

A

As gases mix with water in the airways, so SVP contributes to the pressure in the lungs

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12
Q

What is tension?

A

Equal to the partial pressure, exerted by gases when dissolved in fluid
NOT equal to the amount dissolved, cause gas can react with components

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13
Q

How do you work out how much gas is in fluid?

A

Amount of gas dissolved in a fluid= tension x solubility

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14
Q

What are the branches after the terminal bronchioles?

A

The respiratory bronchioles
The alveolar ducts
Alveolar sacs (surrounded by pulmonary capillary network)

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15
Q

Give some features of the pulmonary circulation

A

Low resistance
Low pressure
Receives the whole cardiac output
Matched by ventilation via hypoxic vasoconstriction

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16
Q

How is the thoracic cavity volume increased (for quiet inspiration)?

A

Requires work to increase space
Diaphragm contracts
External Intercostal Muscles

Breathing out is passive recoil

17
Q

What muscles are used in forced expiration?

A

Internal Intercostal Muscles

Abdominal Muscles

18
Q

Why would we have forced expiration?

A

Obstruction
Exercise
Disease States

19
Q

Define compliance

A

The stretchiness of the lungs, higher compliance is higher stretch
= volume change/ unit pressure change

20
Q

What disease increases lung compliance?

A

Emphysema

21
Q

What disease decreases compliance?

A

Lung Fibrosis

22
Q

How do the lungs reduce surface tension?

A

Surfactants

They prevent the alveoli from collapsing and one well perfused one becoming enlarged

As lungs expand surfactants get further from each other which keeps the surface tension the same

23
Q

Describe Respiratory Distress syndrome

A

Babies born Premature
Lungs are stiff as don’t have enough surfactants
They have few, large alveoli
Breathing and GE is compromised

Can also occur post-trauma

24
Q

What is resistance?

A

The opposition to flow through the airways

25
Q

How do we work out resistance?

A

Pressure/Rate of Flow

8 x Viscosity x Length / Pi r^4

26
Q

How does resistance change?

A

Most comes from upper tract (smaller ones have lower pressure as in parallel)
Higher Resistance in forced expiration harder as lung is compressed

27
Q

Describe Obstructive Airway Disease

A

Small airways are narrowed by disease e.g. Asthma, Chronic Bronchitis
Resistance increases earlier in expiration
Breathing out can be difficult

28
Q

Define Fick’s 1st Law

A

Law of diffusion

Movement of molecules across a barrier is proportional to permeability x surface area x gradient

29
Q

What are the values of pO2 and pCO2?

A

pO2 13.3kPa

pCO2 5.6kPa

30
Q

How are alveolar and arterial partial pressures related?

A

In a normal patient, the values are the same

31
Q

What 2 Factors does diffusion resistance depend on?

A

The nature of the barrier - thickness, distance, surface area

The nature of the gas - diffusion co-efficient

32
Q

The Permeability of the Barrier equation =

A

(Diffusion Co-efficient x Solubility) / Thickness

33
Q

Diseases associated with Resistance

A

Fibrotic Lung Disease - Increase thickness

Pulmonary Oedema - Increase distance

34
Q

What is AVR?

A

The alveolar ventilation rate

(The Total Volume - Anatomical Dead Space) x Respitation Rate

35
Q

Define Serial Dead Space

A

Anatomical DS aka Volume of the Airways
about 150ml
Measure: Nitrogen Washout

36
Q

Define Distributive Dead Space

A

Dead/Damaged Alveoli, Alveoli with poor Perfusion
Don’t support gas exchange
Add to Serial DS

37
Q

What is Physiological Dead Space?

A

Serial + Distributive Dead Space

38
Q

Alveolar Ventilation Rate equation

A

AVR = Pulmonary Ventilation Rate - (Physiological Dead Space x Resp Rate)

39
Q

Look up Lung Function Tests

A

[Poster]