Reservoirs, Transboundry, Epi Curves Flashcards

1
Q

Who is John Snow

A

First published that cholera is transmitted by fecal-oral route and in water supply

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2
Q

Who is Robert Koch?

A

First to isolated bacterium B. Anthracis

Germ therory

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3
Q

Who is Ronald Ross?

A

Guy who discovered Malaria is transmitted by mosquitos

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4
Q

Who discovered that yellow fever is transmitted by mosquitos

A

Walter Reed

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5
Q

What is a habitat in which an infectious agent normally lives, grows, and multiplies?

A

Reservoir

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6
Q

What are three conditions that qualify something as a reservoir?

A

Is it naturally infected with pathogen
Can it maintain the pathogen over time
Can it transmit the disease to a new susceptible host

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7
Q

T/F: infection=disease=infectivity

A

False

Clinically ill animals that are reservoir commenter are probably infectious but so are asymptomatic animals

Not all sick animals are reservoirs

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8
Q

what is a vehicle of transmission?

A

An inanimate object which serves to communicate disease

Common vehicles= food, water, and IV drugs
Fomites=object that can be contaminated and transmit disease on a limited scale

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9
Q

What are the three levels of disease control

A

State
Federal
International

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10
Q

What is a problem with associated with vaccinating against reportable diseases?

A

Vaccines can show up as false positive results

Usually a positive result –> culling

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11
Q

What percent of emerging diseases are affecting humans are of animal origin?

A

75%

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12
Q

What is the OIE classification of notifiable disease?

A

Transmissible disease with potential for very serious and rapid spread, irrespective of national borders, that are of serious socio-economic or public health consequence and that are of major importance in the international trade of animals and animal products

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13
Q

What is infestation?

A

Invasion but not multiplication of an organism in/on a host (fleas/ticks, sometimes parasites)

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14
Q

What does it mean for a disease to be contagious?

A

Disease is transmissible form one human/animal to another via direct or airborne routes

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15
Q

What is a communicable disease?

A

Disease caused by an agent capable of transmission by direct, airborne, or indirect routes from an infected person, animal, plant, or contaminated inaanimate reservoir

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16
Q

Waves on an epidemic curve are separated by?

A

Incubation period

17
Q

Epidemic curve that has a single group of new cases, shaped like a bell curve

A

Common source single point exposure

All animals exposed at the same time
Not contagious

18
Q

Epidemic curve with random spikes, no clear pattern

A

Common source with intermittent exposure

All animals exposed at different times from the same source
Incubation period is not clearly shown

19
Q

Epidemic curves with intermittent waves that progressively increase in size

A

Propagated source

Exposure if followed by “waves” of secondary and tertiary cases
Contagious disease

20
Q

What does it mean for a disease to be endemic?

A

All factors influencing disease are relatively stable

New cases occur at low levels, regularly
Young individuals may enter population
Old individuals die or are removed

21
Q

What are determinants of disease?

A
Host susceptibility  
Social 
Economic 
Physical environment 
Individual characteristics 
Behavior 
Genetics
22
Q

What is a primary disease determinant?

A

major contributing factor to disease

MUST ALWAYS be there for disease to occur

23
Q

What are secondary disease determinants?

A

Factors that make the disease more or less likely

24
Q

What is the difference between and intrinsic and extrinsic disease determinant?

A

Intrinsic - internal to animal (age, breed, sex)

Extrinsic- external to animal (housing, medical treatment, ect)

25
What are disease determinants of the agent?
Mutations -increase infectivity/ability to infect/new toxins/immune system evasion Resistance -mutation or lateral transfer
26
What are environmental determinants?
``` Demographics Macro climate Micro climate Housing and crowding Diet Stress ```
27
What are host determinants
Genotype Breed -> genetic susceptibility Nutrition Immunity ->overall health status
28
T/F: Diet and the animals nutritional status are intrinsic determinants of disease
False Diet is extrinsic, management issue Body condition and animals nutritional status are intrinsic
29
T/F: immunity from a vaccine is an extrinsic factor, but the status of the body being immune is an intrinsic factor
True
30
What is an emerging disease ?
PREVIOUSLY UNKNOWN disease that appears in a population KNOWN disease suddenly appears in a new population
31
What is a RE-emerging disease?
KNOWN disease previously on the decline is becoming more common
32
What are the stages of cross-species disease emergence
1. Pathogen exclusive to animal reservoir 2. Animal reservoir transmits to humans or animals but NO transmission among them(dead end hosts) 3. Animal reservoir tra mists to human/animals with few transmission cycles among them 4. Animal reservoir transmits to human/animals with sustained transmission among them 5. Pathogen exclusive to humans/new animals
33
What makes a disease likely to emerge?
``` Geographic host spot of emergency Host sp traits Host abundance Viral prevalence in host Epidemiological/contact interface ``` Host breath Proportion known zoonoses in family Phylogenic relatedness to those zoonoses
34
What are the 4 main drivers for pathogen emergence??
Land use changes (e.g. fraking/mining) Food and agricultural systems (eg increased production/crowing/uniform genetics) Environmental systems (eg hurricanes) Human behavior (eg travel and tourism)