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Semester 4 > Repro Session 10 > Flashcards

Repro Session 10 Flashcards

1
Q

What is parturition?

A

Scientific term used to describe than transition from the pregnant state to the non pregnant state at the end of gestation

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2
Q

What is labour as a non-scientific term?

A

Describes part of parturition when both the cervix and uterus have been remodelled

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3
Q

What term might lay people use to mean the same as parturition despite it having a different scientific meaning?

A

Labour

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4
Q

What is the term used if parturition occurs at >24 weeks gestation?

A

Spontaneous abortion

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5
Q

What is the term used if parturition occurs at 24-36 weeks of gestation?

A

Pre-term

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6
Q

What is the term used if parturition occurs at 37-42 weeks of gestation?

A

Term

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7
Q

What is the term used if parturition occurs at >42 weeks of gestation?

A

Post-term

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8
Q

Why are pregnancies >42 weeks gestation induced?

A

To avoid foetal and maternal mortality

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9
Q

What are the 3 stages of labour?

A

Creation of the birth canal; expulsion of the foetus; expulsion of the placenta and contraction of the uterus

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10
Q

At what stage during gestation is the uterus palpable?

A

12th week

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11
Q

Where can the fundus be palpated at 20 weeks gestation?

A

Umbilicus

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12
Q

Where will the fundus extend to at 38 weeks?

A

Xiphisternum

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13
Q

Why does the fundal height reduce at term?

A

Foetus adopts position for birth

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14
Q

What is foetal lie?

A

Relationship of foetal long axis to the long axis of the uterus

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15
Q

What is foetal lie usually?

A

Longitudinal (foetal and maternal vertebral columns //)

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16
Q

Is the foetus normally flexed or extended?

A

Flexed

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17
Q

What is foetal presentation?

A

Which part of the foetal head is adjacent to the pelvic inlet

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18
Q

What term is used to describe a presentation when the head is next to the pelvic inlet?

A

Cephalic

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19
Q

What does podalic presentation mean?

A

Foetal buttock is adjacent to pelvic inlet

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20
Q

What does breech presentation describe?

A

Presentation where anything except the foetal crown is adjacent to the pelvic inlet

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21
Q

What can be said about foetal lie if neither the head nor buttocks is palpable at the pelvic inlet?

A

Must be either in transverse or oblique lie

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22
Q

Where is the foetal head in oblique lie?

A

Iliac fossa

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23
Q

Where is the foetal head in transverse lie?

A

Flank

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24
Q

What is the foetal vertex?

A

Relationship of foetus along its axis determining the orientation of the presenting part

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25
Q

What is the most common foetal positioning for birth?

A

Longitudinal lie, cephalic presentation and vertex to pelvic inlet at minimum diameter

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26
Q

What is the largest diameter in normal presentation of the foetus?

A

AP diameter of head at 9.5 cm

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27
Q

What is the typical diameter of the pelvic inlet?

A

11 cm

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28
Q

What determines the birth canal diameter?

A

Pelvic inlet

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29
Q

What does cervical dilatation rely on?

A

Contractions, pressure of foetal head on cervix, ability of cervix to soften and allow distension

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30
Q

What tissues other than the cervix must change to allow for the second stage of labour?

A

Soft tissues of vagina and perineum

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31
Q

What causes cervical ripening?

A

Prostaglandins and hormonal influences

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32
Q

What does the oestrogen:progesterone ratio need to be to allow for the prostaglandins necessary for cervical ripening?

A

High

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33
Q

What are the effects of the relative drop in progesterone seen in labour?

A

Cervical ripening and promotion of contractions

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34
Q

What are the results of prostaglandin and hormonal action in cervical ripening?

A

Decreased collagen, increased glycosaminoglycans, increased hyaluronic acid, decreased aggregation of collagen fibres

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35
Q

What causes the decrease in cervical collagen during cervical ripening?

A

Expression of collagenases in the cervix

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36
Q

What causes an increase in hyaluronic acid during labour?

A

Rubbing of foetal head on membranes creating blisters

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37
Q

What is the action of decorin in cervical ripening?

A

Unwinds collagen strands allowing for further enzymatic degradation

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38
Q

Why do uterine contractions occur throughout reproductive life?

A

Action of pacemaker cells at the top of the fundus

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39
Q

Can uterine contractions during the normal menstrual cycle be detected by the woman?

A

No, amplitude is too small

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40
Q

What change in uterine smooth muscles causes progression of uterine contractions?

A

Thickening

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41
Q

Describe uterine contractions in early pregnancy.

A

Low amplitude every 30 mins as in the normal menstrual cycle

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42
Q

Describe the uterine contractions seen in mid-pregnancy.

A

Slightly higher amplitude than normal, progressing to Braxton-Hicks contractions

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43
Q

What are Braxton-Hicks contractions?

A

‘Practise’ labour contractions that pull together muscle fibres to form a syncytium so that when labour occurs it responds as a whole to one stimulus

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44
Q

What is the difference between Braxton-Hicks contractions and those seen in labour?

A

In labour there is contraction-retraction where the muscle fibres shorten with each contraction but this does not happen in Braxton-Hicks

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45
Q

When might Braxton-Hicks contractions be mistaken by the mother for labour?

A

In a first pregnancy

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46
Q

Describe the uterine contractions seen in early labour.

A

Variable with raised amplitude and reduction in fibre length after each contraction

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47
Q

Describe the uterine contractions seen in late labour.

A

More frequent and high amplitude

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48
Q

What is the clinical definition of labour?

A

More than 3 contractions each lasting a minute within the space of 10 minutes

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49
Q

What causes an increase in amplitude of uterine contraction during labour?

A

Prostaglandin synthesis by the myometrium and decidua of the uterine isthmus increasing calcium movement with each action potential

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50
Q

What increases the frequency of uterine contractions during labour?

A

Why toxin release from the uterine fundus lowering action potential threshold

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51
Q

What happens in the Ferguson reflex?

A

Afferent impulses from the cervix and vagina cause positive feedback on the hypothalamus and posterior pituitary resulting in oxytocin release

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52
Q

What is brachystasis?

A

Where uterine myometrium relaxes less than it contracts causing muscle fibre shortening

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53
Q

What is the result of brachystasis in labour?

A

Drives presenting part of foetus to the cervix

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54
Q

What causes induction of oxytocin receptors on the uterus?

A

Oestrogen

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55
Q

What is the result of increased oxytocin receptor number?

A

Stimulation of uterus to contract and placenta to produce prostaglandins

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56
Q

What happens to the cervix during effacement?

A

Thins and flattens

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57
Q

What is the latent phase of cervical dilatation?

A

Slow dilation of cervix up to 3 cm taking several hours

58
Q

What is the active phase of cervical dilatation?

A

Much faster rate of cervical dilation from 3 cm onwards with onset of pain and amniotic membrane rupture (if it hasn’t already)

59
Q

What diameter is achieved by the end of the active phase of cervical dilatation?

A

10 cm

60
Q

How long do the latent and active phases of cervical dilatation usually take altogether?

A

24 hours

61
Q

How is labour initiated in sheep?

A

Rise in foetal cortisol –> decreased placental progesterone –> increased prostaglandins and myometrial sensitivity to oxytocin –> high oestrogen:progesterone ratio

62
Q

Why can the mechanism of labour initiation identified in sheep not be applied to humans?

A

Human foetuses with congenital adrenal hypoplasia are born and there is no consistent evidence of an increase in the oestrogen:progesterone ratio in humans

63
Q

How is surfactant linked with the initiation of labour in humans?

A

Thought that surfactant protein A activates macrophages in the endometrium causing prostaglandin synthesis in the myometrium

64
Q

How long does the second stage of labour usually take?

A

Up to an hour

65
Q

What does the duration of the second stage of labour depend on?

A

Parity

66
Q

What does the second stage of labour describe?

A

Period of full dilatation of the cervix to delivery

67
Q

What happens to the likelihood of spontaneous delivery of the second stage of labour takes more than an hour?

A

Decreases

68
Q

What is the passive stage of labour?

A

From full dilatation to the desire to push

69
Q

What happens in the passive stage of labour?

A

Internal rotation of foetal head and flexion of foetal neck so that presenting part appears in the birth canal

70
Q

How long does the passive stage of labour last?

A

Usually a few minutes but can be much longer

71
Q

What is the active stage of labour?

A

Mother pushing

72
Q

What causes an irresistible desire to bear down during the active stage of labour?

A

Pressure of foetal head on pelvic floor

73
Q

Why is episiotomy not recommended?

A

Healing will not be along line of weakness thus increasing the risk of poor healing +/- fistula formation

74
Q

Describe the passage of the foetus during delivery.

A

Head delivers in the transverse plane it entered the pelvis, then rotates and extends, shoulders follow and rotate to be delivered with the aid of lateral body flexion anteriorly and posteriorly for everything else to follow

75
Q

Compare the time taken for delivery of the foetus in nulliparous vs multiparous mothers.

A

40 vs 20 mins

76
Q

What is the third stage of labour?

A

Time from delivery of foetus to placental delivery

77
Q

How are uterine contractions involved in the third stage of labour?

A

Their effect is rapidly increased by the expulsion of the foetus so that it contracts hard down to almost its pre-pregnancy size causing shearing of the placenta

78
Q

How can shearing of the placenta be encouraged?

A

Gentle tug on the umbilical cord

79
Q

What do uterine contractions following the expulsion of the placenta reduce the risk of?

A

Haemorrhage

80
Q

How can haemorrhage risk be reduced clinically?

A

Oxytocin drug +/- manual fundal massage

81
Q

Why is the first cry used clinically to determine establishment of independent life of the foetus?

A

Shows that the first breath in must’ve been taken in order to cry

82
Q

What stimuli can cause the first breath to be taken?

A

Trauma, cold, light, noise

83
Q

What is the effect on arterial pO2 of taking the first breath?

A

Increases from 4 kPa to 13 kPa

84
Q

What does clamping of the umbilical cord lead to in order to establish independent life?

A

Ductus venosus closure

85
Q

What does taking the first breath lead to in order to establish independent life?

A

Reduced tissue resistance in the lungs

86
Q

What is the implications for blood flow to the lungs by decreased vascular resistance in establishing independent life?

A

Increases

87
Q

What causes foramen ovale closure to establish independent life?

A

p(R heart) decreases and p(LA) increases

88
Q

What causes closure of the ductus arteriosus?

A

Pressure imbalance causing a reversed flow that exposes its smooth muscle cells to higher pO2 –> contraction

89
Q

Why is failure of ductus arteriosus closure non-pathological in the adult?

A

Pressure differences keep it occluded

90
Q

What does labour mean when used scientifically?

A

Physiologic process by which a foetus is expelled from the uterus to the outside world involving sequential integrated changes in the uterine decidua and myometrium

91
Q

What tends to precede uterine contractions in labour?

A

Changes to uterine cervix

92
Q

What are the 3 Ps of labour?

A

Powers, passenger and passage

93
Q

What is contraction and retraction?

A

Contraction of myometrial fibres followed by partial relaxation causing permanent shortening of the fibres

94
Q

Describe the movement of contractions across the uterus.

A

Originate from 2 poles moving to the fundus and upper uterus to progress down to the lower segment

95
Q

Where are forces of myometrial contraction more powerful?

A

Upper segment of uterus

96
Q

What is the result of retraction in myometrial contraction?

A

Decreases uterine capacity resulting in increased intrauterine pressure

97
Q

What are important passenger considerations in labour?

A

Size, number and position

98
Q

What is transverse foetal lie?

A

Where the long axis of the foetus is perpendicular to that of the mother

99
Q

What is foetal attitude?

A

Whether the foetal head is flexed or extended

100
Q

What is the ideal attitude of a foetus in labour?

A

Maximal flexion

101
Q

Describe the foetal position in frank breech presentation.

A

Buttocks presenting with extended knees

102
Q

Describe the foetal position in full breech.

A

Buttocks presenting with 2 flexed knees

103
Q

What is footling presentation?

A

Where the foot is adjacent to the pelvic inlet

104
Q

What causes alteration of the collagen:ground substance ratio in the cervix during labour?

A

Increased levels of relaxin

105
Q

From what time is enzymatic degradation of collagen in the cervix evident?

A

36 weeks

106
Q

How does enzymatic degradation of collagen in the cervix result in cervical effacement and dilatation?

A

Reduction of resistance to presenting part

107
Q

What causes effacement of the cervix in mid-late pregnancy?

A

Oestrogens, prostaglandins and relaxin

108
Q

What causes effacement and dilatation of the cervix in late pregnancy to term?

A

Retraction of myometrium

109
Q

Describe the gynecoid pelvis shape.

A

Wide pelvic inlet and forepelvis, straight side walls, wide pelvic outlet (subpubic arch)

110
Q

Describe the anthropoid pelvic shape.

A

Narrow transverse inlet, wide AP inlet, divergent forepelvis, narrow side walls

111
Q

Describe the android pelvic shape.

A

Narrow forepelvis, convergent side walls, narrow pelvic outlet

112
Q

What population is the platypelloid pelvic shape commonly seen in?

A

African females

113
Q

What is the impact on engagement of the foetus in mothers with a platypelloid pelvis?

A

Late

114
Q

Describe the platypelloid pelvic shape.

A

Narrow AP diameter, straight forepelvis, wide side walls and pelvic outlet

115
Q

What forms an almost transparent membranous structure seen in the maternal pelvic floor during childbirth?

A

Stretching of levator ani fibres and thinning of the central perineum

116
Q

What can be carried out if the process of labour gets stuck?

A

Caesarean section, forceps or vacuum extraction

117
Q

When does placental separation occur?

A

3rd stage of labour

118
Q

How long does placental separation usually take?

A

5-15 mins but anything up to an hour is considered normal

119
Q

What causes a huge decreases in uterine size following delivery of the foetus?

A

Ongoing contraction and retraction

120
Q

What is the effect of a reduction in the placental site size due to contraction and retraction of the uterus?

A

Inelastic placenta is squeezed

121
Q

What happens to the blood in intervillous spaces during placental separation?

A

Forced back into veins of decidua basalis

122
Q

What inhibits drainage of blood from the intervillous space into the maternal circulation?

A

Retracted uterus

123
Q

Describe the veins in the decidua basalis during placental separation.

A

Tense and congested under pressure by underlying muscle

124
Q

What completed placental separation as contraction and retraction continue?

A

Blood tracking between placenta and decidua

125
Q

Why must bleeding during placental separation be controlled?

A

Normal blood flow is 10-15% of maternal cardiac output

126
Q

What forms ‘living ligatures’ in placental separation?

A

Contraction and retraction causing interlocking of muscle fibres

127
Q

What applies pressure on the placental site once placenta and membranes have been delivered?

A

Apposition of uterus

128
Q

What occurs in the sinuses and torn vessels of placental separation that limits bleeding?

A

Blood clotting

129
Q

What is the most common cause of maternal mortality?

A

Pre-eclampsia/eclampsia

130
Q

Give some causes of maternal mortality other than pre-eclampsia/eclampsia.

A

PPH, obstructed labour, unsafe abortion, pulmonary TB and HIV, ruptured uterus

131
Q

What does rupture of foetal membranes result in that works with phospholipase to increase prostaglandin levels?

A

Disruption of decidual and membrane lysosomes

132
Q

What increases excitability of uterine musculature during labour?

A

Changes to oestrogen:progesterone ratio, oxytocin from maternal posterior pituitary and foetus

133
Q

What increases uterine muscle contractility in labour?

A

Mechanical stretching of smooth muscle, oestrogen increasing gap-junctional communication between cells

134
Q

What can inhibit progesterone during labour?

A

Foetal glucocorticoids and placenta

135
Q

What stimulates prostaglandin synthesis?

A

Increased oestrogen:progesterone ratio and mechanical damage

136
Q

What structures can synthesis prostaglandins?

A

Placenta, decidua and myometrium

137
Q

Why are prostaglandin levels raised in the amniotic fluid early in labour?

A

Amnion increases synthesis during T3

138
Q

What inhibits oxytocin action during pregnancy?

A

Progesterone, relaxin, low receptor number

139
Q

What happens at 36 weeks that allows the uterus to respond to pulsatile release of oxytocin from the maternal posterior pituitary gland?

A

Increased number of receptors in myometrium

140
Q

What does completion of cervical ripening stimulate in the hypothalamus?

A

Stimulation of posterior pituitary to release oxytocin

Semester 4 (33 decks)

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