Head And Neck Session 3 Flashcards
What does the facial skeleton arise from?
Neural crest cell infiltration of the mesenchyme core of PA1
Where do the muscles of mastication originate from?
Mesoderm of PA1
Where do the muscles of facial expression arise from?
Mesoderm of PA2
What are neural crest cells?
Specialised population of cells that originate in the neuroectoderm upon induction by the neural tube (4th germ lineage)
What happens to neural crest cells at the lateral border after being induced by the neural tube?
Displace and ente mesoderm instead of becoming CNS. Then migrate throughout body to give rise to many structures
What are the external features that derive from the FNP?
Forehead, bridge of nose, nose and philtrum
What is located at the base of the stomatodeum?
Buccopharyngeal membrane
What is the external feature that derives from the stomatodeum?
Oral fissure
Where do the cheeks, lateral upper jaw and lip derive from?
Maxillary prominence of PA1
What arises from the mandibular prominence of PA1?
Lower lip and jaw
Describe the process of formation of the nose.
Nose placodes appear on FNP and sink to form nasal pits –> medial and lateral prominences on either side of pit are pushed together by maxillary prominence moving medially –> maxillary fuse with medial nasal –> medial prominences fuse in the midline
What does fusion of the medial nasal prominences create?
Intermaxillary segment consisting of labial component, philtrum, upper jaw, 4 incisors and primary palate
What is the main part of the definitive palate?
Secondary palate
Where is the secondary palate derived from?
Palatial shelves of maxillary prominences
How is the secondary palate formed?
Palatal shelves grow vertically downwards into oral cavity either side of tongue –> mandible enlarges –> tongue drops –> palatal shelves fuse in the midline
What initially separates the nasal pit and oral cavity but quickly degenerates?
Oronasal membrane
How does the nasal septum form?
Mid-line down growth that fuses with palatal shelves
What is the cause of lateral cleft lip?
Failure of fusion of medial nasal prominence and maxillary prominence
What is the cause of lateral cleft lip involving the primary palate?
Failure of fusion of medial nasal prominence and maxillary prominence
What is the cause of cleft lip and cleft palate?
Failure of fusion of medial nasal prominence and maximally prominence combined with failure of palatal shelves to meet in the midline
What are the consequences of cleft lip and left palate?
Difficulty suckling and with speech
What is the fate of the FNP?
Forehead, bridge of nose and medial and lateral nasal prominences
What is the fate of the medial nasal prominence?
Philtrum, primary palate and mid upper jaw
What is the fate of the lateral nasal prominence?
Sides of the nose
What is the fate of the maxillary prominence?
Cheeks, lateral upper lip, secondary palate and lateral upper jaw
What is the fate of the mandibular prominence?
Lower jaw and lip
When does development of the eyes begin?
In the 4th week at the3-vesical brain stage
How do the eyes develop?
Forebrain pouches grow outwards –> met overlying ectoderm (optic placodes) –> optic placode invaginates and pinches off
What forms the lens of the eye in the developed foetus?
Optic placodes
Where does the retina derive from?
Diencephalon (forebrain) as part of the optic vesicle
What transforms to give the optic nerve?
Optic stalk
What causes humans to have binocular vision?
Growth of facial prominences pushing eye primordia from the side of the head to the front of the face
What do all common chromosomal abnormalities have associated anomalies with?
External ear
What arises in the neck to form the external ear?
External auditory meatus from 1st pharyngeal cleft and auricles from proliferation of PA1&2 surrounding meatus
What causes ascension of the ears from the neck to be in line with the eyes on the sides of the head?
Mandible growth
How is the inner ear formed?
Otic placodes invaginate to form auditory vesicles and membranous labyrinth forms cochlea and semi-lunar canal system
What is foetal alcohol syndrome?
Exposure of the developing foetus to alcohol causing disruption to neural crest cell migration and brain development causing characteristic facial features and severe restriction of cognitive development
What is alcohol-related neurodevelopment disorder (ARND)?
CNS, behavioural and learning dysfunction due to alcohol exposure in utero without characteristic facial features of FAS
What are the characteristic facial features seen in FAS?
Short palpebral fissure lengths Smooth philtrum Thin upper lip Short, upturned nose Microcephaly
What is the incidence of FAS and ARND?
1 in 100 births
What drives development of the face?
Expansion of the cranial neural tube, appearance of complex tissue systems, development of sense organs and need to separate resp from GI tracts
What is the function of the cervical spine?
Support skull, allow a large range of movement, provide passage for descending nerves
What type of curvature does the cervical spine have?
Secondary
What ligaments support the cervical spine?
Anterior and posterior longitudinal Ligamentum flavum Interslinous ligament Nuchal ligament Transverse ligament of atlas
Where are the anterior and posterior longitudinal ligaments positioned?
Along bodies and discs of the vertebral column