Repro Endocrinology Flashcards
All hormone receptors are __
proteins
Progesterone, estrogen and testosterone are all __ based and have a __ charge
cholesterol, neutral
Steroid hormone receptors are located in the __
nucleus
FSH + LH bind to follicle cells in the ovary which results in synthesis of a new product __
Estradiol
GNRH source, target tissue and primary action in females
source: hypothalamic surge and tonic centers
Target tissue: anterior pituitary
Primary action: release FSH + LH
LH source, target tissue and primary action in females
Source: anterior pituitary
Target tissue: ovary (theta internal + luteal cells)
Primary Action: stimulates ovulation, form corpora lutea + progesterone secretion
FSH source, target tissue and primary action in females
Source: anterior pituitary
Target tissue: ovary (granulosa cells)
Primary action: follicular development + estradiol synthesis
GNRH source, target tissue and primary action in males
Source: hypothalamic surge and tonic centers
Target tissue: anterior pituitary
Primary action: release FSH and LH
LH source, target tissue, and primary action in males
Source: anterior pituitary
Target tissue: testis
Primary action: stimulate testosterone production
FSH source, target tissue, primary action for males
source: anterior pituitary
Target tissue: testis (serotonin cells)
Primary action: Sertoli cell function
Hypothalamic- pituitary- gonadal - axis
primary reproductive regulatory system for puberty, seasonality, cyclicity
Gonadotrophin Releasing Hormone travels locally to the pituitary via a __ while it travels systemically to the gonads via __
portal vein, general circulation
FSH and LH are both __
gonadotropins
gonadal hormones of the testis including leydig cells secrete __ while sertoli cells secrete __
testosterone, inhibin
leydig cells -> testosterone -> anterior pituitary = __
suppress FSH
FSH -> sertoli cells -> T to DHT and E2 -> hypothalamus = __
suppress FSH
also secretes inhibin for negative feedback on FSH
what gonadal hormones does the follicle secrete?
estrogen
progesterone
inhibin
what gonadal hormones does the CL secrete
Progesterone
low levels of estrogen have __ feedback on GnRH, FSH and LH while high levels have __ feedback
positive, negative
progesterone has __ feedback on GnRH, FSH, and LH
negative
inhibin has negative feedback on __ only
FSH
gonadectomy results in very __ levels of gonadotropins because there is a lack of __
high, feedback
prostaglandin is primary from the __ and is responsible for __
endometrium , luteolysis
how can prostaglandin be used clinically?
- shorten the estrus cycle
- eliminate progesterone production
- evacuate the uterus
