Repro Drugs

Question 1

Drug given in pulsitile fashion for infertitiy. MoA?

Answer 1

Leuprolide. GnRH analogue

Question 2

Pt with uterine fibroids. Side effects of drug?

Answer 2

Leuprolide. Nausea and vomiting

Question 3

Pt with prostate cancer - 2 drug combo?

Answer 3

leuprolide and flutamide

Question 4

Drugs that block testicular production of testosterone?

Answer 4

Ketoconazole, Spirolactone (Shoot and Kill testies)

Question 5

Drugs that block binding of DHT/T to receptor?

Answer 5

Flutamide, cyproterone, spirolactone (SPI-CY FLUTe)

Question 6

Drugs that block Anti Pit secretion of FSH/LH?

Answer 6

OCP, danazol

Question 7

Drug that block aromatase?

Answer 7

Anastrozole

Question 8

Drugs that block estrogen binding to receptor?

Answer 8

Fulvestrant

Question 9

Pediatric with burns. Possible consequence of giving this post-burn drug to children?

Answer 9

Testosterone. Closure of epiphyseal plate (also up LDL, down HDL)

Question 10

Adult pt with hypogonadism. Side effect of drug?

Answer 10

Testosterone. Increases LDL and decreased HDL (can close epipyseal plates in children)

Question 11

MoA of drug that makes boobs bigger (women) and decreases hair loss (men)

Answer 11

Finasteride. 5a-reductase inhibitor (Five-Alpha = FinAsteride)

Question 12

Inhibits 17,20 desmolase. Use in this disease. Similar drug?

Answer 12

Ketoconzaole. PCOS to prevent hirsutism. ALso spirolactone

Question 13

Pt with androgen-dependent prostate cancer?

Answer 13

Estrogens (mestranol)

Question 14

Increases risk of clear cell carconoma in women?

Answer 14

DES (estrogen)

Question 15

Contraindications for estrogen?

Answer 15

DVT, ER-positive breast cancer

Question 16

SERM used for infertility. MOA

Answer 16

Clomiphene - partial ag. Used to block E feedback in pituitary, increasing FSH/LH.

Question 17

SERM used for older female with low bone density? MOA

Answer 17

Raloxifene - agonist in bone (prevent osteoporosis)

Question 18

MoA of SERM used in breast cancer. Risk?

Answer 18

Tamoxifen. Antagonist on breast, agonist in uterus (increase risk of endometrial cancer)

Question 19

Postmenopausal women with breast cancer. MoA of Drugs?

Answer 19

Anastrozole, exemestane (aromatase inhibitors)

Question 20

Reduces growth and increases vascularization of endometrium?

Answer 20

Progestins

Question 21

Pt comes in with Heavy bleeding, nausea, vomiting, and without an appetite after abortion. MoA of Drug given?

Answer 21

Mifepristone. Competitive inhibitor of progesterone

Question 22

Mifepristone given with what other drug?

Answer 22

Misoprostol (PGE1)

Question 23

Do not given to smokers, estrogen-dependent cancer pts, or pts with clotting disorder?

Answer 23

OCP (progestins, estrogens)

Question 24

OCP - MoA?

Answer 24

Estrogen/Progesterone inhibits LH/FSH surge -> no ovulation

Question 25

b-HCG MoA?

Answer 25

produces LH

Question 26

MoA of drug to reduce uterine contractions?

Answer 26

Terbutaline. B2-agonist.

ter-B(2ag) U(terus)-aline

Question 27

MoA of drrug to treat older male pt with trouble urinating.

Answer 27

Tamulosin. alpha-1a,d-antag for BPH. Selective for prostate receptors.

Question 28

MoA of drugs to used treat prostate cancer.

Answer 28

SilDENAFIL, VarDENAFIL (fill the penis). inhibits phosphodiesterase 5 increasing cGMP, relaxing smooth muscle and increasing blood flow.

Question 29

Pt with heatburn, hypotension, and impaired headache? Side effects of?

Answer 29

sildenafil and vardenafil

Question 30

distortions in blue-green color vision. Side effect of?

Answer 30

Sildenafil and vardenafil

Question 31

Used for endometriosis and angioedema?

Answer 31

Danazol

Question 32

Pt with history of swelling (runs in family) on a drug that has increased acne, hirsutism, and decreased HDL?

Answer 32

Danazol

Question 33

Hepatoxicty is a side effect of this drug that is a partial receptor at androgen receptors?

Answer 33

Danazol