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Pharm > Neuro Pharm - Opioids and Glaucoma > Flashcards

Neuro Pharm - Opioids and Glaucoma Flashcards

1
Q

MoA of glaucoma drug that cannot be used in closed-angle glaucoma.

A

Epinephrine - decreases aqueous humor synthesis via vasoconstriction

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2
Q

MoA of Glaucoma drug that can cause itching or foreign body sensation of eye?

A

Brimonidine -a2 agonist - decreases aqueous humor synthesis

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3
Q

B-blockers used in glaucoma?

A

Timolol, Betaxolol, Carteolol

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4
Q

MoA of diuretic used for glaucoma?

A

Acetazolamide - decreases aqueous humor synthesis via inhibition of carbonic anhydrase

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5
Q

MoA of direct cholinomimetics (2) used for glaucoma?

A

Pilocarpine and cabachol. Increased outfow of aqueous humor via contraction of ciliary muscle and opening of trabecular meshwork

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6
Q

Glaucoma drugs that may lead to miosis and cyclospasm

A

Pilocarpine and carbachol

cyclospasm - contraction of ciliary muscle

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7
Q

Glaucoma drug used in emergencies?

A

pliocarpine

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8
Q

Indirect cholinomimetics used for glaucoma?

A

Physostigmine, Echothiophate

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9
Q

MoA of prostaglandin used used for glaucoma?

A

Lantanoprost. PGF-2alpha. Increases outflow of aqueous humor

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10
Q

Glaucoma drug that may darken color of Iris?

A

Latanoprost

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11
Q

Opioids - tolerance does not develop to?

A

miosis and constipation

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12
Q

Opioid used for cough?

A

Dextromethorphan

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13
Q

Opioid used for diarrhea (2)

A

Loperamide and diphenoxylate

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14
Q

Pulmonary indication for opioid use?

A

acute pulmonary edema

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15
Q

Opioid used for addiction programs?

A

methadone

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16
Q

Anti-opioids (2)

A

naloxone and naltrexone

17
Q

Meperidine?

A

Opioid

18
Q

diphenoxylate?

A

Opioid for diarrhea

19
Q

fentanyl?

A

Opioid

20
Q

dextromethorphan?

A

Opioid used for cough

21
Q

MoA for opioids? (NTs affected)

A

Opens K, close Ca - decrease transmission of ACh, 5HT, NE, glutamate and substance P

22
Q

MoA of opioid used for severe pain (migrane, labor)?

A

Butrophanol. Mu-partial agonist and kappa-agonist.

23
Q

Opioid that is not not easily reversed with naloxone?

A

Butorphanol

24
Q

Causes less respiratory depression than other opioids?

A

Butrophanol

25
Q

Weak Opiod agonist?

A

Tramadol

26
Q

MoA for opioid used for chronic pain?

A

Tramadol. Opioid ag that inhibits 5HT and NE reuptake

27
Q

Overview: classes of drugs that

1) decrease aqueous humor synthesis
2) increase outflow

A

1) epinephrine, a2-agonists , b-blockers, diuretics

2) direct cholinomimetics, indirect cholinomimetics, prostaglandins

27
Q

Opioid that can decrease seizure threshold?

A

Tramadol

28
Q

drug with similar MoA to butorphan?

A

Pentazocine

Pharm (15 decks)

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