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Anti-Microbials Flashcards

1
Q

Chemoprophylaxis for meningococcus?

A

Rifampin

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2
Q

Antibiotic with MAO-I properties? (can cause serotonin syndrome)

A

Linezoid

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3
Q

Penicillian - used for?

A

Mostly gram+ rods (Strep pneumo, strep pyo, actinomyces)

Also spirochetes, meningitdis

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4
Q

Penicillian MoA?

A

bind transpeptidases that cross-link membrane

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5
Q

interstitial nephritis - adverse effect of what antibiotic?

A

Naf-, Oxa, Dicloxa- cillian

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6
Q

Psudomembranous colitis and rash - what antibiotic?

A

Ampicillian/Amoxicillian

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7
Q

Ampicillian/Amoxicillian kills?

A 
Enterococci - HELPSS
H flu
E coli
Listeria
Proteus
Salmonella
Shigella
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8
Q

Antibiotic for psuedomonas?

A

Ticarcillian, Pipercillian

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9
Q

Cephalosporins do not cover?

A

LAME

Listeria, Atypicals (chlaydia, mycoplasma), MRSA, Enterococci

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10
Q

Only cephalosporin to cover MRSA?

A

Ceftaroline

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11
Q

1st gen Cephaosporin? kills?

A

Cefazolin. PEcK

Proteus, E coli, Klebsiella

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12
Q

2nd generation Cephaosporins? kills?

A

Cefoxitine, Cefaclor, cefuroxime.
HENS PeCK
H Flu, enterobactor, Neisseria, Serratia, Proteus, E coli, Klebsiella

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13
Q

Cephaosporin for meningitis and gonorrhea?

A

Ceftriaxone

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14
Q

Cephaosporin for pseudomonas?

A

Cefazidime,

CeftAZidime for pseudomonAZ

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15
Q

Vit K deficieny with what antimicobes?

A

Cephaosporin

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16
Q

These drugs increase this toxicity of aminoglycosides?

A

Cephaosporin increase nephrotoxicity

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17
Q

Use against gram-negative rods?

18
Q

Drug that binds to PBP3 is synergistic with this drug?

A

Aztreonam. Aminoglycosides

19
Q

This PBP binding drug can be given to people with a penicillan allergy?

20
Q

MoA of drug that is administered with Imipenem?

A

Cilastatin - inhibitor of renal dehydropeptidase

21
Q

Toxicity of vancomycin?

A

NOT that common

Nephrotoxicity, Ototoxicity, Thrombophlebitis and Red Man syndrome

22
Q

Affect 30S subunit?

Affect 50S subunit?

A

Aminoglycosides, Tetracyclines

Chloramphenicol, Clindamycin
Erythromycin
Linezolid

23
Q

Aminoglycosides used for?

A

aerobic gram-negative rods

24
Q

Aminoglycosides - toxicity?

A

Mean GNATS caNNOT kill anerobes

"ear shaped" body parts
Nephrotoxicity 
Neuromuscular blockade
Ototoxicity
Teratogen
25
Q

Tetracycline used as a diuretic?

A

Demeclocycline (used for SIADH)

26
Q

Decreased absorption of tetracyclines with?

A

milk, antacids, divalent cations

27
Q

Clindamycin used to treat?

28
Q

To treat anaerobes above diaphragm vs treat anerobes below diaphragm?

A

Clindamycin vs metronidazole

29
Q

Sulfonamides - MoA? Used for?

A

PABA antimetabolites inhibit dihydropteroate synthesis

gram positives, negatives, chlamydia and nocardia

30
Q

Sulfonamides - toxicities?

A

Sulfa - hemolysis, nephrotoxicity, photosensitivity, kericterus

31
Q

Trimethoprin - MoA? Use?

A

Inhibit dihydrofolate reductase. Used with Sulfoamides for UTIs, shigella, salmonella, PCP

32
Q

Trimethoprin - toxicities?

A

Megaloblastic anemia

33
Q

Fluoroquinolones used for? Mech?

A

gram neg rods (including pseudomonas), neisseria. Inhibit DNA gyrase and topoisomerase

34
Q

Fluroquinolones - toxicities?

A

tendon rupture, dysglycemia, prolonged QT

35
Q

Metronidazole - use for?

A

GET GAP
Giardia, entamoeba, trichomonas
Gardnerella, anaerobes (bacteriodes, c diff) and h pylori

36
Q

Metronidazole - do not take?

A

Alcohol - disulfiram-like reaction

37
Q

TB drugs?

A

RIPE - rifampin, isonizaid, pyrazinamide, ehtanmbutol

38
Q

MAI drugs?

A

Azithromycin, rrifampin, ethambutol, streptomycin

39
Q

Leprae drugs?

A

Dapsone, rifampin

40
Q

isoniazid MoA?

A

precent mycolic acid synthesis

Pharm (15 decks)

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