Renal Pharm

Question 1

Drugs that act in the PCT?

Answer 1

Mannitol and Acetazolamide

Question 2

Pt with increased ICP and IOP? Diuretic that can be given?

Answer 2

Mannitol

Question 3

pulmonary edema and dehydration are Toxicities of what diuretic?

Answer 3

Mannitol

Question 4

Pt with CHF. Do not give this diuretic?

Answer 4

Mannitol

Question 5

Pt with anuria. Contraindicated diuretic?

Answer 5

Mannitol

Question 6

Drug that causes self-limited NaHCO3 diuresis. Uses? cause what type of acid-base disturbance?

Answer 6

Acetazolamide. Used for Glaucoma, metabolic alkylosis, altitude sickness, pseudotumor cerebri. Hyperchloremic Acidosis

Question 7

Pt treated for altitude sickness. Comes in with NH3 toxicity. Drug?

Answer 7

Acetazolamide

Question 8

Pt treated for pseudotumor cerebri. Comes in with paresthesias. Other toxicities

Answer 8

Acetazolamide. HyperCl Metabolic acidosis ammonia toxicity, sulfa allergy

Question 9

Drugs that work in TAL?

Answer 9

Loop diuretics and Ethacrynic acid

Question 10

Drug that abolishes hypertonicity of medulla, preventing concentration of urine. Can cause excretion of what electrolytes?

Answer 10

Loop diuretics (furosemide). Excretion of Ca and K

Question 11

Pt on that drug that stimulates PGE release to vasodilate AA. Toxicities?

Answer 11

Furosemide - OH DANG
Ototoxicity
HypoK
Dehydration
Allergy
Nephritis
Gout

Question 12

Pt on this drug for diuresis in loop of henle has sulfa allergy. Derived from? Never use it to treat?

Answer 12

Ethacrynic acid. Phenoxyacetic acid. Can cause hyperuricemia, never use to treat gout

Question 13

Drug that should never be given with pt with gout?

Answer 13

Ethacrynic acid (can cause hyperuricemia)

Question 14

Diuretic that may cause hyperCa, may also cause?

Answer 14

HCT. Hyper-glycemia, -lipidemia, -uricemia, -calcemia

Question 15

This diuretic can be used for nephrogeneic diabetes insipidus?

Answer 15

HCT

Question 16

This diuretic can be paradoxically used for idiopathic hyperCa?

Answer 16

HCT

Question 17

Diuretic for CHF?

Answer 17

HCT or K-sparing

Question 18

K sparing diuretics?

Answer 18

The K STAys

Spirolactone, Amiloride, Triamterene and eplerenone

Question 19

Diuretics that can cause gynecomastia, also block?

Answer 19

Spirolactone and eplerenone. Block ALDO

Question 20

Diuretics that may cause acidosis?

Answer 20

Carbonic Anhydrase inhibitors (decrease HCO3)

K-sparing (decreases K/H secretion)

Question 21

MoAs Diuretics that may cause Alkalemia?

Answer 21

Loop diuretics and thiazides

1) increase HCO3 while volume contracting
2) K loss leads to H entering cells
3) In low K states, H is excreted in exchange for Na

Question 22

Ca increased with this diuretic? Decreased with this?

Answer 22

thiazides; loop

Question 23

Diuretic that can prevent unfavorable heart remodeling as a result of chronic hypertension?

Answer 23

ACE-Is

Question 24

ACE-Is - side effects?

Answer 24

CATCHH
Cough
Angioedema
Teratogen
Creatinine increase (down GFR)
HyperK
Hypotension

Question 25

Avoid using this diuretic if patient has bilteral renal artery stenosis?

Answer 25

ACE-Is