ONC

Question 1

Cancer Drug that works during:
G1?
S?
G2?
M?

Answer 1

G1? none
S? antimetabolities/etoposide
G2? bleomycin, etoposide
M? Vinca alkaloids and taxols

Question 2

Decreases thymidine synthesis?

Answer 2

Methotrexate

5FU

Question 3

Decreases purine synthesis?

Answer 3

6-MP

Question 4

crosslink DNA

Answer 4

Alkylating agents, cisplatin

Question 5

Intercalate DNA?

Answer 5

Dactinomycin, doxorubicin

Question 6

inhibits topoisomerase II?

Answer 6

etoposide, doxorubicin

Question 7

inhibits microtubule formation?

inhibits microtubule disassembly?

Answer 7

Vinca alkaloids, paclitaxel

Question 8

Methotrexate: uses?

Answer 8

Cancers: Leukemias, lymphomas, chorioCA, osteoCA
non: cancer: abortion, ectopic pregnancy, RA, psoriasis

Question 9

MTX can cause myelosuppression. Reversible with? Drug that causes myelosuppression not reversible in same way?

Answer 9

Leucovorin. 5FU

Question 10

Cancer pt comes in with microvesicular fatty change in liver. Cause?

Answer 10

MTX

Question 11

Use for topical cancers (basal cell CA, etc). Side effect?

Answer 11

5-FU. Photosensitivity

Question 12

5FU MoA?

Answer 12

Pyrimidine analog, complexes folic acid, inhibiting formation of dTMP.