Renal transporters Flashcards by Kira Harms

Q

proximal tubule function

A

incr salts/H2O reabsorption
H+/drugs secretion

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Q

PT transporters

A

Na/K ATPase
NHE
SGLT

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Q

NHE is inhibited by

A

ANG2
carbonic anhydrase inhibitors

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Q

SGLT is inhibited by

A

SGLT inhibitors

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Q

DLOH function

A

concentrating
H2O reabsorption

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Q

ALOH function

A

diluting
salts OUT

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Q

ALOH transporters

A

NKCC2
NHE
Na/K ATPase
K+ leak

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Q

NKCC2 is inhibited by

A

loop diuretics

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Q

loop diuretics are

A

Ca2+ wasting
K+ wasting

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Q

NKCC2 is upregulated by

A

ADH

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Q

NaK+ ATPase is upregulated by

A

ADH

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Q

DT function

A

fine tuning
diluting
favors reabsoprtion
adjusts salts/pH

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Q

DT transporters

A

NCC

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Q

what inhibitrs NCC

A

thiazide diuretics

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Q

thiazide diuretics are

A

K+ wasting

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Q

PTH

A

on DT incr Ca2+ reabsorption

Q

Calbindin

A

in DT binds to Ca2+ and prevents secretion

Q

PTH and calbindin are unpregulated by

A

thiazides

Q

CCD transporters

A

ROMK
BK
ENAC
AQP2
Na/K ATPase

Q

ROMK/BK function

A

K+ secretion

Q

ENAC function

A

Na+ reabsoprtion

Q

AQP2

A

H2O reabsorption

Q

what upregulated ROMK/BK

A

aldosterone

Q

what inhibits ENAC

A

amelioride

what upregulates ENAC

ADH aldosterone

what upregulates AQP2

ADH

what upregulates Na/K ATPase

ADH Aldosterone

Type A intercalated cells overall effect

reabsorb: HCO3- / K+ secrete: H+/Cl-

Type B intercalated cells overall effect

reabsorb: H+ secrete: HCO3- / K+

Type A cells are upregulated by

aldosterone

MCD reabsorbs

Na+ Cl- H2O Urea HCO3-

MCD is upregulated by

ADH

early nephron

glomerulus PT DLOH

mid nephron

ALOH DT CD