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Su: Phys 2 > Body Fluids > Flashcards

Body Fluids Flashcards

1
Q

TBW equation

A

TBW = ICF + ECF

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2
Q

TBW

A

42 L

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3
Q

ICF

A

28L

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4
Q

ECF

A

14 L

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5
Q

ECF =

A

ECF = IF + Plasma

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6
Q

IF

A

11L

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7
Q

Plasma

A

3L

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8
Q

primary driver of ICF tonicity/volume

A

K+

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9
Q

primary driver of ECF tonicity/volume

A

NaCl

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10
Q

ICF composition

A

high K+
high Mg2+
High Protein
High HPO4-

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11
Q

ECF composition

A

High Na+
High Ca2+
High Cl-
High HCO3-

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12
Q

plasma composition

A

high Na+
high Ca2+
High Cl-
High HCO3-
High protein

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13
Q

is the concentration of proteins higher in the ECF or the plasma?

A

Plasma

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14
Q

Gibbs donnan effect

A

semi permeable membrane results in uneven distribution of particles

attach more cations
repel more anions

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15
Q

osmolarity

A

dilution of particles in 1 L of fluid

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16
Q

osmolality

A

dilution of particles in 1 kg of fluid

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17
Q

primary disposal site for K+

A

skeletal muscle cells

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18
Q

causes of hyperkalemia

A

hyperosmolarity
exercise
cell lysis
acidosis

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19
Q

causes of hypokalemia

A

insulin
beta agonist
aldosterone
alkalosis

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20
Q

normokalemia

A

3.5-5.5 mEq/L

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21
Q

hypokalemia

A

< 3.5 mEq/L

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22
Q

hyperkalemia

A

> 5.5 mEq/L

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23
Q

hypokalemia can cause

A

delayed ventricle repolarization

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24
Q

hypercalemia can cause

A

arrythmias
VFib

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25
resting membrane potential
RMP ~ [K+]icf / [K+]ecf
26
hypokalemia ____ RMP
decreases RMP = harder to depolarize
27
hyperkalemia _____ RMP
incr RMP = easier to depolarize
28
hypokalemia ECG changes
delayed ventricle repolarization peaked P wave prolonged PR ST depression shallow T wave U wave
29
hyperkalemia ECG changes
VFib wide/flat P wave prolonged PR decr R wave wide QRS ST depression tall/peaked T wave
30
what controls fluid movement between plasma and ICF
starling forces
31
what controls fluid movements between ECF and ICF
osmosis (AQP)
32
the renal system takes _______ to line up with changes in intake
2-3 days
33
NET Na+ retention effects
incr ECFV decr RAAS Incr ADH
34
hypervolemia trends towards
pulm edema
35
hypovolemia trends towards
decr organ perfusion
36
tonicity
gradient between ICF and ECF
37
isotonic
no net fluid movment
38
hypotonic
[ECF] < [Cell] fluid move INTO cell Swell incr Hct
39
hypertonic
[ECF] > [Cell] fluid move OUT of cell shrink decr Hct
40
what stops fluid movement
the 2 fluids become isotonic to each other
41
crystalloids
cross semi-perable membrane
42
isotonic crystalloid
LR 0.9% saline
43
hypertonic crystalloids
3% saline mannitol
44
hypertonic crystalloid indication
hyponatremia brain swelling
45
hypotonic crystalloids
0.45% saline 5% dextrose
46
hypotonic crystalloid indication
hypernatremia
47
how are crystalloids categorized
based on [electrolyte] in solution vs plasma
48
colloids
HES/dextrans
49
colloids last
long duration in intravascular space
50
colloid mechanism
incr plasma oncotic P draw H2O from extravascular to blood vessels mx blood volume
51
60 (60-40-20 rule)
TBW ~ 0.6(weight in kg)
52
40
ICF ~ 0.4(weight in kg)
53
20
ECF ~ 0.2(weight in kg)
54
TBW markers
3H2O 2H2O antipyrine
55
ICF markers
none
56
ECF markers
22Na inulin mannitol
57
ISF =
ISF = 3/4 ECF
58
plasma =
plasma = 1/4 ECF
59
plasma markers
125I-albumin evans blue
60
TBV
TBV = plasma vol/(1-Hct)
61
ICF = (fat adjusted)
ICF = 0.67 TBW
62
ECF = fat adjusted
ECF = 0.33 TBW
63
what pts should use the fat-adjusted TBW
female infant elderly
64
volume contraction
decr ECFV
65
volume expansion
incr ECFV
66
isoosmotic
300 mOsm
67
hyperosmotic
> 300 mOsm
68
hyposmotic
< 300 mOsm
69
sweat containrs
more H2O than Na+
70
sweat causes
decr ECF incr plasma Osm
71

Su: Phys 2 (12 decks)

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