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Rx Prep > Renal Disease - Quiz 4 > Flashcards

Renal Disease - Quiz 4 Flashcards

1
Q

Where do thiazides work?

A

DCT

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2
Q

Where do K sparing diuretics work?

A

DCT and collecting ducts

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3
Q

Where do loop diuretics work?

A

Ascending loop of henle

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4
Q

Where do SGLT2I work?

A

PCT

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5
Q

Drugs that cause nephrotoxicity?

A
  1. Aminoglycosides
  2. Amphotericin B
  3. Cisplatin
  4. Cyclosporine
  5. Loops
  6. NSAIDs
  7. Polymyxins
  8. Radiographic dyes
  9. Tacrolimus
  10. Vanc
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6
Q

What lab do we take to assess kidney function?

A
  1. BUN
  2. sCr
  3. eGFR
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7
Q

Normal sCr range?

A

0.6-1.3

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8
Q

What is the criteria for CKD?

A

eGFR <60
Albuminuria ≥30

Greater than 3 months

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9
Q

G1

A

> 90

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10
Q

G2

A

60-89

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11
Q

G3a

A

45-59

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12
Q

G3b

A

30-44

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13
Q

G4

A

15-29

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14
Q

G5

A

<15

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15
Q

A1

A

<30

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16
Q

A2

A

30-300

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17
Q

A3

A

300+

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18
Q

What is the tx for HTN with CKD?

A

ACEI and ARBs despite race

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19
Q

Tx for diabetes and CKD

A

SGLT2i, finerenone

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20
Q

Anti-infectives that requrire renal dosage adju?

A
  1. Aminoglycosides
  2. Beta-lactams (except antistaph (nafcillin, oxacillin), ceftriaxone
  3. FLuconazole
  4. Quinolones (not moxifloxacin)
  5. Vanc
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21
Q

CV drugs that require dosage adj?

A
  1. LMWH (enoxaparin)
  2. Rivaroxaban
  3. Apixaban
  4. Dabigatran
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22
Q

GI drugs that require renal dose adjustment?

A
  1. H2RAs
  2. Metoclopramide
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23
Q

Other drugs that require dosage adj?

A
  1. Bisphosphanates
  2. Lithium
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24
Q

Drugs that are CI with CKD?

A
  1. Nitrofurantoin
  2. TDF, TAF
  3. Voriconazole
  4. NSAIDs
  5. Dabigatran
  6. Metformin
  7. Meperidine
  8. Rivaroxaban
  9. SGLT2I
25
Q

Tx for hyperphosphatemia?

A
  1. Reduced phosphate intake (avoiding dairy, cola, chocolate, nuts)
  2. Phosphate binders that block absoprtion of dietary phosphate
26
Q

What to do if you miss dose of phosphate binder?

A

Skip til next dose

27
Q

Aluminum based phosphate binders?

A
  1. AALuminum hydroxide
28
Q

Alumnium hydroxide ADRs?

A

Aluminum intoxication

29
Q

Calcium based phosphate binder?

A
  1. Calcium acetate
  2. Calcium carbonate
30
Q

ADRs of calcium based phosphate binder?

A
  1. Hypercalcemia
  2. Constipation
  • Concomitant ue of vit D can cause hypercalcimium
31
Q

What are the aluminium and calcium free phosphate binders?

A
  1. Sucroferric oxyhydroxide (Velphoro)
  2. Ferric citrate
  3. Lanthanum carbonate (Fosrenol)
  4. Sevelamer carbonate (Renvela)
  5. Sevelamer HCl (Renagel)
32
Q

ADR of Sucroferric and ferric citrate?

A

Constipation

33
Q

ADRs of lanthanum carbonate?

A
  1. NV
  2. Diarrhea
  3. COnstipation
34
Q

ADR of sevelamer?

A
  1. NVD
  • Lower LDL
35
Q

What drugs should be separated from phosphate binders?

A
  1. levothyroxine
  2. Quinolones
  3. Tetracyclines
36
Q

MOA of calcimemetic

A

Mimics that action of calcium on the parathyroid gland and reduces PTH

37
Q

Vitamin D2

A

Ergocalciferol

38
Q

Vitamin D3

A

Cholecalciferol

39
Q

What is the active form of Vitamin D?

A

Calcitriol

40
Q

ADR of calcitriol

A

Hypercalcemia
* Take with food to decrease GI upset

41
Q

Types of calcimimetics?

A
  1. Cinacalcet
  2. Etelcalcetide
42
Q

Cinacalcet

A

Sensipar

43
Q

Sevelamer carbonate

A

Renvela

44
Q

Sevelamer HCl

A

Renagel

45
Q

Tx for ESA

A
  1. epoetin alfa (Procrit, Epgen, Retacrit)
  2. Darbepoetin alfa (Aranesp)
46
Q

Indicaion for ESA

A

Hgb <10, DC is >11 to prevent risk of TED

47
Q

What should be given with ESA?

A

IV iron

48
Q

Drugs that cause increase potassium?

A
  1. ACEI
  2. Aliskirin
  3. ARBs
  4. Canagliflozin
  5. Drospirenon COC
  6. Potassium
  7. Potassium sparing
  8. Bactrim
  9. Transplant drugs
49
Q

How do you treat hyperkalemia?

A
  1. Stabilize heart
  2. Move potassium
  3. Remove potassium
50
Q

Drugs used to stabilize heart?

A
  1. Calcium gluconate
  2. Calcium chloride
51
Q

Drugs that move potassium

A
  1. Regular insulin with D5W (to prevent hypoglycemia)
  2. Sodium bicarb (metabolic acidosis)
  3. Albuterol
52
Q

Drugs used to remove K?

A
  1. Loops
  2. SPS
  3. Patiromer
  4. SZC
  5. Hemodialysis
53
Q

Types of potassium binder>

A

SPS, Patiromir, SZC

54
Q

ADR for SPS

A

CI necrosis, binds to other meds

55
Q

ADR for patiromer

A
  1. Hypomagnesia
  2. Constipation
  3. Binds to other drugs (separate by 3 hrs)
  4. Delayed onset
56
Q

ADR of SZC

A

Separte from other drugs by 2 hr

57
Q

Tx for metabolic acidosis?

A
  1. Sodium bicarb
  2. Sodium citrate
58
Q

Factors to consider for dialysis med?

A
  1. Molecular weight/size
  2. Vd
  3. Protein-binding
  4. Memebrane
  5. Blood flow rate

Rx Prep (15 decks)

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