Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Rx Prep > BPH - Quiz 3 > Flashcards

BPH - Quiz 3 Flashcards

1
Q

How is testosterone metabolized?

A

Broken down to DHT by 5-alpha reductase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is BPH?

A

Overgrowth of the stromal and epithlial cells of the prostate gland

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the drugs that worsen BPH?

A
  1. Centrally-acting anticholinergics
  2. Drugs with anticholinergic effects (antihistamine, decongestants, phenothiazines, TCAs)
  3. Caffeine
  4. Diuretics
  5. SNRIs
  6. Testosterone products
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How is BPH diagnosed?

A
  1. Digital rectal exam for size of prostate
  2. Prostate specific antigens and urinanalysis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

S/s of BPH?

A
  1. Hesitancy, intermittent urine flow, straining, weak stream
  2. Urgency, leaking, and dribbling
  3. Frequency, nocturia
  4. Incomplete emptying
  5. Bladder obstruction
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Natural products for BPH?

A
  1. Saw palmetto
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Natural products for prostate cancer prevention?

A

Lycopene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Drug classes for BPH?

A
  1. alpha-blocker
  2. 5-alpha reductase inhibitor
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What drug class is used to decrease prostate size?

A

5-alpha reductase but delayed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

When can anticholinergics be used for BPH?

A

PVR <250-300 mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

PDE5I that is indicated for BPH?

A

Tadalafil (Cialis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the pathophys of intraoperative floppy iris syndrome (IFIS)

A

If a patient is using an alpha blocker while having catarat surgery, the iris becomes floppy and pupil is unable to dilate properly
* blockers use should be delayed until after surgery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the firstline tx for moderate-severe BPH sx?

A

alpha 1 blockers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

MOA of alpha 1 blockers?

A

Inhibit alpha-1 adrenergic receptors causing relaxation of smooth muscle
* Reduces bladder obstruction and improves urine flow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What non selective alpha blockers have more ADRs?

A

Terazosin
Doxazosin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are your selective alpha-A1 blockers?

A

Tamsulosn
Alfuzosin
Silodosin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

When are non selective alpha blockers dosed?

A

Before bed to avoid orthostasis and dizziness from first dose
* TItrate slowly

18
Q

Doxazosin

A

Cardura, Cardura XL

19
Q

Terazosin

A

Hytrin

20
Q

Tamsulosin

A

Flomax

21
Q

ADR of alpha blockers?

A
  1. DZ
  2. Fatigue
  3. HA
  4. Abnormal ejaculation
  5. Hypotension, syncope
22
Q

How long does it take for alpha blockers to reach beneficial effects?

A

Works quickly on LUTs, 4-6 wks for beneficial effects
* However, doesn’t shrink prostate and change PSA levels

23
Q

Describe the formulation of Cardura XL

A

OROS tablet w/ ghost tablet

24
Q

What drug can cause retrograde ejaculation that is reversable upon discontinuation?

A

Silodosin

25
Q

What drug is cautioned when co-administering with alpha blockers?

A

PDE5I due to hypotesion
* Tadalafil should not be combined with alpha blockers if it was for the treatment of BPH

26
Q

What alpha blcokers are CYP3A4 substrates?

A
  1. Tamsulosin
  2. Alfuzosin
  3. Silodosin
27
Q

What alpha blocker causes QTc prolongation?

A

Alfuzosin

28
Q

MOA of 5-alpha reductase inhibitors?

A

Blocks the conversion of testosteron to DHT
* Improves sx
* Reduce size of prostate and PSA levels
* Decrease risk for uinary retention
* Decrease need for surgery

29
Q

What surgeries are used for BPH?

A

TURP (Transurethral resection of the prostate)
Prostatectomy

30
Q

Finasteride

A

Proscar
Propecia (alopecia)

31
Q

Dutsteride

A

Avodart

32
Q

Alfuzosin

A

Uroxatral

33
Q

Silodosin

A

Rapaflo

34
Q

CI of 5-alpha reductase inhibitors?

A

Women of child bearing potential
Pregnancy
* Pregnant women shouldn’t take or handle med

35
Q

ADR of 5-alpha reductase inhibitors?

A
  1. Impotence
  2. Decreased libido
  3. Ejaculation disturbances
  4. Breast enlargement and tenderness
36
Q

How long does it take for 5-alpha reductase inhibitors to reach maximal effect?

A

6 months

37
Q

Can a patient be on both Proscar and Propecia?

A

NO

38
Q

What is the difference between Cialis and Adcirca

A

Cialis is for BPH and ED
Adcirca is for PAH

39
Q

CI for tadalafil?

A

Co-administration with nitrates

40
Q

ADRs of PDE5 inhibtors?

A
  1. Color discrimination
  2. Hearing loss
  3. Vision loss from NAION
  4. Hypotension
  5. Chest pain
  6. Priapsim
  7. HA, flushing, DZ, dyspepsia, back pain
41
Q

Starting dose of tadalafil for BPH?

A

5 mg PO QD

42
Q

Dosing of Tamsulosin for BPH?

A

0.4 mg PO QD

Rx Prep (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions