Renal cell cancer

Question 1

what is it also known as?

Answer 1

hypernephroma

Question 2

how many primary renal neoplasms does it account for

Answer 2

85%

Question 3

associations with renal cell cancer

Answer 3

more common in middle-aged men
smoking
von Hippel-Lindau syndrome
tuberous sclerosis
incidence of renal cell cancer is only slightly increased in patients with autosomal dominant polycystic kidney disease

Question 4

Classic triad of renal cell cancer

Answer 4

haematuria
loin pain
abdominal mass

Question 5

other symptoms of renal cell cancer

Answer 5

pyrexia

endocrine effects

mets

varicocele

Stauffer syndrome

paraneoplastic hepatic dysfunction syndrome

Question 6

What is Stauffer syndrome?

Answer 6

paraneoplastic disorder associated with renal cell cancer

Question 7

how does stauffer syndrome present?

Answer 7

cholestasis/hepatospenomegaly

secondary to increased level of IL-6

Question 8

Mx

Answer 8

partial or total nephrectomy

alpha-interferon and interleukin-2

receptor tyrosine kinase inhibitors e.g. interferon-alpha