Renal

Question 1

explain how ACEi can cause significant first-dose hypotension

• which groups most susceptible
• how to reduce risk

Answer 1

pts with volume depletion (eg from diuertic use)
or heart failure

ACEi abruptly removes the vasoconstrictive effects of antiotensin II, resulting in decreased peripheral vascular tone and drop in BP

start ACEi at low doses and alowly incr as needed

Question 2

eplerenone and spironolactone are what type of drug

-side effects?

Answer 2

aldosterone antagonists

hyperK
incr Cr
Gynecomastia (more so in sironOlactOne)