Biochem/Genetics Flashcards
1
Q
impaired tetrahydrobiopterin synthesis will result in?
A
-deficient serotonin, tyrosine, and DOPA
BH4 is a cofactor in synth
2
Q
what two things can cause PKU
A
BH4 deficiency due to dihydropteridine reductase deficiency (converts BH2 to BH4) –> low Phe diet and BH4 supplement
phenylalanine hydroxylase
