Other Uworld things

Question 1

drug of choice for status epilepticus

-what is its MOA

Answer 1

IV benzodiazepene

enhanced postsynaptic chloride influx

Question 2

treatment for heparin overdose

Answer 2

protamine sulfat

binds heparin, forming a complex with no anticoagulant acitivty

Question 3

treatment for warfarin overdose

Answer 3

Fresh frozen plasma

Vitamin K (takes days)

Question 4

what drug poisoning is like a superwarfarin

Answer 4

most rodenticides have brodifacoum, a long acting 4-hydroxycoumarin derivative

pt who’s ingested enough rat poisoning to cause coagulopathy and abnml bleeding needs immed tx with ffp and vitamine K (like warfarin poisoning)

Question 5

arsenic poisoning

• moa
• sources
• symptoms
• Tx

Answer 5

binds sulfhydryl groups, disrupts cellular respiration and gluconeogenesis

pesticides, insecticides; contaminated water (wells); pressure treated wood

Acute: garlic breath, vomiting, diarrhea, QTc
Chronic: hypo/hyperpigmentation, hyperkeratosis, stocking glove neuropathy

Dimercaprol
DMSA

Question 6

risk factors bladder cancer (2)

Answer 6

smoking

occupational exposures – rubber, plastics, aromatic amine containing dyes, textiles, leather

Question 7

explain retinopathy of prematurity

Answer 7

premature babies have resp distress syndrome

tx includes high conc O2. temporary local hypoxia in the retina upon return to room air stim VEGF and cause abnormal neovascularization in retina. may result in retinal detachment with blindness