Renal 3 Flashcards
Infection assd with cryoglobulinemia
Hep C
Most frequent GN worldwide
IgA nephropathy
Location of staining in IgA nephropathy
mesangium
This helps differentiate IgA nephropathy from lupus
C1q is pos in lupus, neg in IgA
Class 1 and 2 lupus
Class 1: normal histology
Class 2: mesangial lesion
Class 3 and 4 lupus
Class 3: focal proliferative GN
Class 4: diffuse proliferative GN
Class 5 lupus
membranous nephropathy
Most common and most severe lupus
class 5
differential of crescentic GN (3)
Immune-complex mediated,
Pauci-immune,
Anti-GBM
Pauci-immune crescentic GN usually assd with..
ANCA
Most common ANCA in microscopic polyangiitis
p-ANCA
Wegener and MPA cause
pauci-immune crescentic GN
Target in anti-GBM
NC1 domain of tpe IV collagen
LM in anti-GBM
cellular crescents (macrophages, PMNs, lymphs, podocytes, fibrin) become fibrous crescents
IF in anti-GBM
linear IgG of GBM
Thrombotic microangiopathies involving kindey (5)
HUS, TTP, malignant HTN, anti-phospholipid syndrome, cyclosporin/tacrolimus toxicity
Histo of HUS and TTP
fibrin thrombi in capillaries and small arteries, ischemic collapse of glomeruli, RBC fragments
Mutation in Alports
type IV collagen
X-linked: C terminal of alpha 5 chain
(Others alpha 3 or alpha 4)
EM in Alports
irregular contours of GBM
“basketweave”
Lesion seen on LM in Alports
Interstitial foam cells
Thin GBM dz clinical and EM
hematuria with normal renal function
GBM <200 nm
Flattening of tubular epithelium with loss of brush borders with granular casts
ATN (ischemic or toxic)
Interstitial inflammatory infiltrate (lymphs, PCs, Eos, granulomas
Drug-induced acute interstitial nephritis
Acute renal allograft rejection
tubulitis, interstitial inflammation, endothelitis, transmural necrosis of arteries
Chronic renal allograft rejection
intimal thickening of arteries, ischemic changes
3 findings in cyclosporin/tacrolimus toxicity
- tubular epithelial vacuolization
- hyaline artiopathy
- thrombotic microangiopathy
Diseases usually presenting with nephrotic syndrome (4)
Minimal change,
FSGS,
Membranous,
Diabetic,
Disease usually presenting with nephritis syndrome (2)
Post-infectious,
Crescentic glomerulonephritis
Renal dzs assd with Hep C
Membranoproliferative,
Cryoglobulinemia
