Renal 1 Flashcards
Glomerulopathie involving epithelial cells only (1)
Minimal change
Glomerulopathies involving epithelial cells and basement membrane (2)
FSGS,
Membranous
Gomerulopathies involving basement membrane only (5)
Diabetes, Amyloid, Light chain deposition dz, Alports, Thin basement membrane dz
most common cause of nephrotic syndrome in children
minimal change
EM findings n minimal change
effacement of epithelial foot processes
Most common cause of idiopathic neprhotic syndrome in AA adults
FSGS
secondary causes of FSGS (5)
Obesity, sickle cell, pre-eclampsia, reflux nephropathy, unilateral kidney
Nephropathy that may have intracapillary foam cells
FSGS
Aggressive variant of FSGS
collapsing
IF in FSGS
negative or non-specific
EM of FSGS
foot process effacement, epithelial cell vacuolization
HIV nephropathy on LM
collapsing FSGS
HIV nephropathy on EM
tubulo-reticular inclusions in epithelial cells (also seen in lupus)
Diseases with tubulo-reticular inclusions on EM
HIV and Lupus
Most common cuase of idiopathic nephrotic syndrome in white adults
membranous nephropathy
LM of membranous nephropathy
capillary loops thickened
Silver stain in membranous
“spikes”
IF in membranous
granular IgG adn C3 on capillary loops
Granular IgG and C3 on capillary loops
Membranous
“spikes”
membranous
Location of deposits in membranous
subepithelial
Stage 1 membranous
subepithelial deposits without GBM thickening
Stage 2 membranous
“spike and dome”
Stage 3 membranous
deposits completely surrounded by GBM
Stage 4 membranous
“moth-eaten” GBM, deposits resorbed
Secondary causes of membranous (5)
RA, Drugs (gold, penicillamine), paraneoplastic, Hep B and C, lupus
IF of lupus nephritis
C1q deposits
Classic lesion of diabetic nephropathy
Kimmelstiel-Wilson nodules
IF of diabetic nephropathy
nonspecific linear IgG and albumin on BM
Em of diabetic
diffuse thickening of GBM
