Molecular stuff Flashcards

1
Q

10q deletion

A

small cell astrocytoma (>90%)

- these also have EGFR amplification

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2
Q

22q deletion

A

ATRT
DiGeorge
Meningioma

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3
Q

i17q

A

medulloblastoma

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4
Q

Myc amplification

A

medulloblastoma (poor prognosis)

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5
Q

meningioma assd deletions

A

22q (most common), 1p, 14q

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6
Q

IDH1 mutation

A

favors secondary GBM over de novo

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7
Q

70% of small cell GBMs have

A

EGFR mutation

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8
Q

most common mutation in GBM

A

loss of ch 10

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