Renal Flashcards
Post-streptococcal GN is characterized by what?
Decreased C3, normal C4
ASO titers >90%
LM: diffuse proliferative
IF: starry sky (diffused granular deposition of IgG C3
EM: large dense immune deposits in the subendothelial, subepithelial, mesangial
Characteristics of immune complex glomerulonephritis
Decreased C3, (-) ANCA, anti-GBM
IF: starry sky (diffused granular deposition of IgG C3 is associated with which type of GN?
Post-strep GN
Crescentic GN is seen in which type of GN?
RPGN
Anti-GBM nephritis + lung hemorrhage is associated with which condition?
Goodpasteur’s syndrome
Diffused effacement of foot processes of visceral epithelial cells is seen in which type of nephrotic syndrome?
Minimal change disease
80% seen in children
IF: (-) Ig C3
Treatment: steroids
Hyalinosis of <50% of glomeruli is associated with which condition?
Focal segmental glomerulonephritis
IF: (-) Ig
EM: damage to visceral epithelial cells
Poor prognosis
Wire loop abnormality is seen in which condition?
Type IV SLE nephropathy
Immune complex deposition & gross thickening of the BM
Decreased C3 glumerulonephritis
Post strep GN; Membrano-proliferative GN
IF revealed lumpy-bumpy appearance is associated with what type of glomerulonephritis?
Post strep GN
IgA deposition in the mesangium is associate with which disease?
Berger disease
Tram track appearance is seen in which type of glomerulonephritis?
Membrano-proliferative GN
White cell casts in the urine is associated with what condition?
Acute pyelonephritis
Proximal renal tubular dysfunction leading to impaired reabsorption is associated with what syndrome?
Fanconi syndrome
Impaired reabsorption of tryptophan/deficiency in tryptophan?
Hartnup disease
Thyroidization of the kidneys is seen in which condition?
Chronic pyelonephritis
Schistosoma haematobium is associated with what type of renal cell?
Squamous cell CA
Most common location of renal cell CA
Upper pole
Hematogenous dissemination
Most common cause of nephrosclerosis in adults?
Membranous glomerulopathy
Diffused thickening of the GBM
(+) PAS
IgA nephropathy associated with gross hematuria 24-48 hours after an infection or strenous exercise
Berger’s disease
Earliest renal abnormality in DM patients?
Glomerular hyperinflation
Fibrinoid, “onion-skin” lesions of the kidneys is associated with which type of nephrosclerosis
Malignant arteriolar nephroscerlosis
What is Type 1 renal tubular acidosis?
Distal, inability to secrete H+ and develop high K+ in urine
Alkalinic urine
Treatment: oral HCO3, K replacement
What is type II renal tubular acidosis?
Inability to absorb HCO3
Associated with bone lesions (osteomalacia and rickets)
Treatment: potassium, thiazide diuretics
What is the defect in renal tubular acidosis type IV?
Aldosterone deficiency or adrenal insensitivity to angiotensin II
Asymptomatic hyperkalemia
Tx: Fludrocortisone (mineralocorticoid)
Most common hereditary renal disorder
Adult polycystic kidney disease
Bilateral cyst
Also related to berry aneurysm of the circle of Willis
IF revealing spike and dome appearance
Membranoglumerulonephritis
Kimmelstiel-Wilson nodules is associated with what condition?
DM nodular glumerulosclerosis
Nodular accumulations of mesangial matriax material
