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Patho > Hematopoietic/Lymphoid > Flashcards

Hematopoietic/Lymphoid Flashcards

0
Q

Most common cause of hereditary thrombophilia

A

Factor V leiden (resistance to protein C)

2nd most common cause: Prothrombin 20210A transition

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1
Q

Neutropenia + albinism + cranial and peripheral neuropathy + repeated infections

A

Chèdiak-Higashi Syndrome

Autosomal recessive

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2
Q

Iron deficiency + partially obstructing esophageal web is seen in which condition?

A

Plummer vinson syndrome

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3
Q

SE of Dilantin (Phenytoin)?

A

Folate deficiency

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4
Q

Most common cause of aplastic anemia?

A

Toxin

Others: Benzene, chloramphenicol, alkylating agents, parvovirus, Hep C

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5
Q

G6PD deficiency affects which pathway?

A

Failure of erythrohexose-monophosphate shunt

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6
Q

Defect in sickle cell

A

GAG (glu) > GTG (val)

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7
Q

Most common immune hemolytic anemia?

A

Warm body auto-immune hemolytic anemia

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8
Q

Cold agglutin disease is associated with which blood group antigen?

A

I blood group antigen

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9
Q

Hereditary spherocytosis is a defect in which structure?

A

Spectrin

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10
Q

Bite cells are also associated with which condition?

A

G6PD deficiency

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11
Q

Type of hemoglobin with increased resistance to M. falciparum

A

Hemoglobin S

G6PD deficiency and (-) duffy blood group

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12
Q

Osteomyelitis in patients with sickle cell is due to which organism?

A

Salmonella

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13
Q

Heinz bodies are also seen in which condition?

A

G6PD deficiency

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14
Q

Most common malignancy of children

A

ALL

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15
Q

Type of ALL most responsive to therapy

A

ALL Positive CD10

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16
Q

Autosplenectomy is also seen in which condition?

A

Sickle cell

17
Q

Auer rods is seen in which condtion?

A

AML

18
Q

Smudge cells is associated with?

A

CLL

19
Q

Helmet cells are associated with which condition?

A

Thrombotic thrombocytopenic pupura

Traumatic injury; microangiopathic hemolytic anemia

20
Q

Heterophil-negative infectious mono is also known as?

A

CMV

21
Q

Teardrop-shaped erythrocytes is also seen in which condition?

A

Chronic idiopathic myelofibrosis

22
Q

Heterophil-positive infectious mono is also seen in which condition?

A

EBV

Presents with atypical lymphocytes

23
Q

Waldenstrom macroglobulinemia presents with?

A

M protein, Bence Jones proteins, Plasmacytoid lymphocytes

Important: abscence of bone lesion

24
Q

Lytic bone lesions/punched-out lesions is seen in?

A

Multiple myeloma

25
Q

Binucleated or multinucleated giant cells with eosinophilic inclusion-like nucleoli is also known as?

A

Reed-Sternberg cells

26
Q

Reed-Sternberg cells is seen in which condition?

A

Hodgkin’s lymphoma

27
Q

Most frequently occuring form of Hodgkin lymphoma

A

Nodular sclerosis Hodgkin lymphoma

28
Q

Most common form of non-Hodgkin lymphoma

A

Follicular lymphoma

B-cell lymphoma; t(14;18)

29
Q

Lymphoma that arises from sites of chronic inflammation/autoimmune disease is also known as?

A

MALToma

30
Q

Starry sky appearance is seen in which lymphoma?

A

Burkitt Lymphoma

Cell debris taken up by non-neoplastic macrophages

31
Q

Pautrier microabscesses are seen in which type of infection?

A

Mycosis fungoides

Small pockets of tumor cells w/in epidermis

32
Q

M proteins are seen in?

A

Multiple myeloma

Kappa or lambda light chain

33
Q

Leukemic form of cutaneous T-cell lymphoma is known as?

A

Sezary syndrome

34
Q

Hereditary hemorrhagic telangiectasia is also known as?

A

Osler-Weber-Rendu syndrome

Localized malformations of venules and capillaries

35
Q

Cytogenic change in Burkitt lymphoma?

A

t(8;14); Increased expression of c-myc

36
Q

Bence Jones proteins are seen in which condition?

A

Multiple myeloma

37
Q

Hereditary deficiency of platelet-surface IIb/IIIa

A

Glanzmann thrombasthenia

38
Q

Hereditary lack of GP Ib/IX/V

A

Bernard-Soulier syndrome

39
Q

Dutcher bodies are associated with which condition?

A

Waldenstrom’s macroglobulinemia

PAS (+) with IgM deposits around the nucleus

Patho (14 decks)

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