Hematopoietic/Lymphoid

Question 0

Most common cause of hereditary thrombophilia

Answer 0

Factor V leiden (resistance to protein C)

2nd most common cause: Prothrombin 20210A transition

Question 1

Neutropenia + albinism + cranial and peripheral neuropathy + repeated infections

Answer 1

Chèdiak-Higashi Syndrome

Autosomal recessive

Question 2

Iron deficiency + partially obstructing esophageal web is seen in which condition?

Answer 2

Plummer vinson syndrome

Question 3

SE of Dilantin (Phenytoin)?

Answer 3

Folate deficiency

Question 4

Most common cause of aplastic anemia?

Answer 4

Toxin

Others: Benzene, chloramphenicol, alkylating agents, parvovirus, Hep C

Question 5

G6PD deficiency affects which pathway?

Answer 5

Failure of erythrohexose-monophosphate shunt

Question 6

Defect in sickle cell

Answer 6

GAG (glu) > GTG (val)

Question 7

Most common immune hemolytic anemia?

Answer 7

Warm body auto-immune hemolytic anemia

Question 8

Cold agglutin disease is associated with which blood group antigen?

Answer 8

I blood group antigen

Question 9

Hereditary spherocytosis is a defect in which structure?

Answer 9

Spectrin

Question 10

Bite cells are also associated with which condition?

Answer 10

G6PD deficiency

Question 11

Type of hemoglobin with increased resistance to M. falciparum

Answer 11

Hemoglobin S

G6PD deficiency and (-) duffy blood group

Question 12

Osteomyelitis in patients with sickle cell is due to which organism?

Answer 12

Salmonella

Question 13

Heinz bodies are also seen in which condition?

Answer 13

G6PD deficiency

Question 14

Most common malignancy of children

Answer 14

ALL

Question 15

Type of ALL most responsive to therapy

Answer 15

ALL Positive CD10

Question 16

Autosplenectomy is also seen in which condition?

Answer 16

Sickle cell

Question 17

Auer rods is seen in which condtion?

Answer 17

AML

Question 18

Smudge cells is associated with?

Answer 18

CLL

Question 19

Helmet cells are associated with which condition?

Answer 19

Thrombotic thrombocytopenic pupura

Traumatic injury; microangiopathic hemolytic anemia

Question 20

Heterophil-negative infectious mono is also known as?

Answer 20

CMV

Question 21

Teardrop-shaped erythrocytes is also seen in which condition?

Answer 21

Chronic idiopathic myelofibrosis

Question 22

Heterophil-positive infectious mono is also seen in which condition?

Answer 22

EBV

Presents with atypical lymphocytes

Question 23

Waldenstrom macroglobulinemia presents with?

Answer 23

M protein, Bence Jones proteins, Plasmacytoid lymphocytes

Important: abscence of bone lesion

Question 24

Lytic bone lesions/punched-out lesions is seen in?

Answer 24

Multiple myeloma

Question 25

Binucleated or multinucleated giant cells with eosinophilic inclusion-like nucleoli is also known as?

Answer 25

Reed-Sternberg cells

Question 26

Reed-Sternberg cells is seen in which condition?

Answer 26

Hodgkin's lymphoma

Question 27

Most frequently occuring form of Hodgkin lymphoma

Answer 27

Nodular sclerosis Hodgkin lymphoma

Question 28

Most common form of non-Hodgkin lymphoma

Answer 28

Follicular lymphoma B-cell lymphoma; t(14;18)

Question 29

Lymphoma that arises from sites of chronic inflammation/autoimmune disease is also known as?

Answer 29

MALToma

Question 30

Starry sky appearance is seen in which lymphoma?

Answer 30

Burkitt Lymphoma Cell debris taken up by non-neoplastic macrophages

Question 31

Pautrier microabscesses are seen in which type of infection?

Answer 31

Mycosis fungoides Small pockets of tumor cells w/in epidermis

Question 32

M proteins are seen in?

Answer 32

Multiple myeloma Kappa or lambda light chain

Question 33

Leukemic form of cutaneous T-cell lymphoma is known as?

Answer 33

Sezary syndrome

Question 34

Hereditary hemorrhagic telangiectasia is also known as?

Answer 34

Osler-Weber-Rendu syndrome Localized malformations of venules and capillaries

Question 35

Cytogenic change in Burkitt lymphoma?

Answer 35

t(8;14); Increased expression of c-myc

Question 36

Bence Jones proteins are seen in which condition?

Answer 36

Multiple myeloma

Question 37

Hereditary deficiency of platelet-surface IIb/IIIa

Answer 37

Glanzmann thrombasthenia

Question 38

Hereditary lack of GP Ib/IX/V

Answer 38

Bernard-Soulier syndrome

Question 39

Dutcher bodies are associated with which condition?

Answer 39

Waldenstrom's macroglobulinemia PAS (+) with IgM deposits around the nucleus