Regulation of Patterns

Question 1

Which genes establish the axes in drosophila?

Answer 1

maternal effect genes

Question 2

Which genes establish the basic body plan in drosphila?

Answer 2

zygotic genes

Question 3

What protein does homeobox (hox) code make?

Answer 3

Homeodomain

Question 4

How many complexes are mammalian Hox genes arranged into?

Answer 4

4 complexes

Question 5

Why are there no ribs in the lumbar spine?

Answer 5

Hox10 inhibits their formation

Question 6

What kind of pattern are Hox genes expressed in?

Answer 6

Nested patterns

Question 7

When does limb development take place?

Answer 7

weeks 4-8

Question 8

What controls the development of the different bones of the arm?

Answer 8

several Hox genes

Question 9

What signalling pathways are known to play specific roles in vertabrate development?

Answer 9

1. Wnt signalling
2. Sonic hedgehog signalling
3. TGF-Beta signalling
4. FGF signalling

Question 10

Name some defects caused by defects in Wnt signalling

Answer 10

cancer
osteoarthtitis
bone disorders

Question 11

How many Wnts and frizzled receptors are there in Wnt signalling?

Answer 11

19 Wnts and 10 frizzled receptors

Question 12

Name defects caused by defects in sonic hedgehog singalling

Answer 12

cancers
polydactyly
craniofacial defects

Question 13

Name defects caused by defects in TGF-Beta signalling

Answer 13

cancer

skeletal defects

Question 14

Name defects caused by defects in FGF signalling

Answer 14

skeletal disorders

syndactyly