Regulation of Feeding Flashcards

1
Q

hypothalamic feeding center

A
  • lateral nuclei
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2
Q

stimulation of lateral nuclei

A
  • hyperphagia
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3
Q

destruction of lateral nuclei

A
  • inanition
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4
Q

hypothalamic satiety center

A
  • ventral nuclei
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5
Q

stimulation of ventral nuclei

A
  • refusal to eat
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6
Q

destruction of ventral nuclei

A
  • overeating
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7
Q

lesion to paraventricular nucleus

A
  • increases eating
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8
Q

lesion to dorsal medial nucleus

A
  • decreases eating
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9
Q

orexigenic substances

A
  • stimulate feeding
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10
Q

anorexigenic substances

A
  • inhibit feeding
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11
Q

activation of AGRP/NYP neurons

A
  • increase feeding

- low energy stores: NPY released, reduce POMC firing leading to appetite stimulation

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12
Q

activation of POMC/CART neurons

A
  • decrease feeding while increasing energy expenditure
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13
Q

mutations in MCR receptors

A
  • leads to hyperphagia
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14
Q

C peptide

A
  • secreted with insulin
  • longer half life
  • used as measure of insulin secretion
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15
Q

somatostatin

A
  • inhibits both insulin and glucagon

- secreted from delta cells

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16
Q

IDDM (type 1)

A
  • lack of insulin secretion - destruction of beta cells
  • onset at puberty
  • increased blood glucose
  • treat with insulin replacement
17
Q

NIDDM (type 2)

A
  • decreased sensitivity of target tissue to insulin
  • adult onset
  • increased plasma insulin (initially) and glucose
  • treat by altering diet, then drugs