MEN Flashcards
1
Q
chromosome mutated in MEA I
A
- chromosome 11
2
Q
chromosome mutated in MEA II (A and B)
A
- chromosome 10
3
Q
mutation theory
A
- 2 “hits” required
- first in germ cell line, second in somatic cell line
- first hit causes hyperplasia
- second hit causes tumor development
4
Q
glandular involvement of MEA 1
A
- 3 Ps
- anterior pituitary
- parathyroid
- pancreas
5
Q
parathyroid involvement in MEA 1
A
- most common gland involved in MEA 1
- hyperparathyroidism leads to hypercalcemia in 70%
- primary lesion is an adenoma
6
Q
pancreatic cell types involved in MEA 1
A
- hyperplasia, carcinoma, adenoma
7
Q
symptoms of pancreatic involvement in MEA 1
A
- PUD is most common: multiple ulcers associated with ZES
- hypoglycemia: insulin secreting tumors
- hyperglycemia, dermatitis, anemia, wt loss: glucagonoma
- watery diarrhea and hypokalemia: VIPoma
8
Q
anterior pituitary cell types involved in MEA 1
A
- adenoma
9
Q
symptoms of anterior pituitary involvement in MEA
A
- Cushing’s syndrome: excessive weight gain, bruises easily, slow healing of cuts, acne
- acromegaly
- hyperprolactinemia
10
Q
screening for MEA 1
A
- prolactin
- calcium
- PTH
- phosphate
11
Q
thyroid involvement in MEA IIA
A
- bilateral
- multicentric
- diffuse or nodular hyperplasia of C-cells
12
Q
screening for MEA IIA
A
- calcitonin
13
Q
treatment of thyroid carcinoma
A
- total thryoidectomy is best in patient and in family
14
Q
parathyroid involvement in MEA IIA
A
- very low incidence of hyperparathyoidism
15
Q
adrenal involvement in MEA IIA
A
- can lead to hypertensive crisis and cardiac dysrythmia
- treated with bilateral adrenalectomy
- pheochromocytoma - second most common lesion in MEA IIA, usually bilateral
- NO SCREENING TEST AVAILABLE
