Regulation of Circulation Flashcards
Fairly constant
brain, liver, heart
Needs/supply change
skin, muscles, gut
Systemic circuit
rest of body
Pulmonary circuit
flow to lungs
NO
paracrine hormone
Muscle contraction proteins
actin and myosin
Intracellular Ca2+
needed to enable myosin to bind to actin, normally low levels
electrical signal receieved by muscle fiber releases stores of Ca into muscle fiber cytosol
Action potential
electrical signal that is a self sustaining wave of membrane depolarization, results from the movement of ions across the plasma membrane
Influences on cardiac cycle
electrical, chemical
Cardiac cycle
1) SA node
2) AV node
3) bundle branches
4) Purkinje fibres
Cardiac output
heart rate x stroke volume
Acetylcholine
neurotransmitter, released by nerves to cells of SA ndoe, opens K channels and efflex of K from cells, lowers resting potential of cells
Norepinephrine
released by nerves to cells of SA node, increases Ca2+ and Na influx
Adrenaline
epinephrine. blood borne hormone, nervous stimulation of cardiac output. increases release of Ca into cytosol of ventricular cells and faster removal of these ions. stronger/briefer contractions