Regulation And Energetics Of The Citric Cycle

Question 1

What influences the control of the Citric Acid Cycle?

Answer 1

Cellular ATP demands and regulatory enzymes

Question 2

Which enzyme is inhibited by ATP, NADH, Acetyl-CoA, and Succinyl-CoA?

Answer 2

Citrate Synthase

Question 3

What activates Isocitrate Dehydrogenase?

Answer 3

ADP

Question 4

Which two molecules inhibit Isocitrate Dehydrogenase?

Answer 4

ATP, NADH

Question 5

What inhibits Alpha-Ketoglutarate Dehydrogenase?

Answer 5

Succinyl-CoA, NADH

Question 6

How many NADH are produced in the Citric Acid Cycle?

Answer 6

3 NADH

Question 7

How many ATP are produced from 1 FADH2 in the Citric Acid Cycle?

Answer 7

2 ATP

Question 8

What is the total ATP yield per Acetyl-CoA in the Citric Acid Cycle?

Answer 8

~10-12 ATP

Question 9

What is the net reaction for complete glucose oxidation?

Answer 9

C6H12O6 + 6O2 + 38ADP + 38Pi → 6CO2 + 6H2O + 38ATP

Question 10

How many ATP and NADH are produced during Glycolysis?

Answer 10

2 ATP + 2 NADH

Question 11

How many NADH are produced during Pyruvate Oxidation?

Answer 11

2 NADH

Question 12

What are the total products from the Citric Acid Cycle?

Answer 12

6 NADH, 2 FADH2, 2 ATP

Question 13

Fill in the blank: Complete oxidation of one glucose molecule results in a net ATP production of _______ molecules.

Answer 13

38

Question 14

True or False: Recent evidence suggests the net ATP production from glucose oxidation is closer to 40 ATP.

Answer 14

False