Metabolism Of Triacylglycerols Flashcards
Compare between the 2 pathways of metabolism of triacylglycerols
What are the 2 different steps of lipogenesis
Activation of building units
Condensation
What is the aim of activation of building units
Increase the energy of the molecule for condensation
Explain activation of building units
Explain condensation
What is the fate of newly formed TAGs
Liver and adipose tissue
Explain the fate of TAGs in liver
Explain the fate of TAGs in adipose tissue
Explain why TAGs are main energy store form
What are the steps of lipolysis
In well fed state and fasting state what is active and what is inactive
Well fed state = lipogenesis active, lipolysis inactive
Fasting state = lipogenesis inactive, lipolysis active
What controls the well fed state
Insulin
How does insulin stimulate lipogenesis
- Stimulation of glucose intake by stimulating the glucose transporter
- Stimulate glycolysis
- Stimulate pyruvate dehydrogenase that forms acetylCoA (building block of FA)
- Stimulates the enzyme of FA synthesis ACC
- Stimulates the enzyme of TAGs synthesis acyl transferase
How does insulin inhibit lipolysis
Inhibit hormone sensitive lipase by dephosphorylation
What are the hormones of the fasting state
How hormones in fasting state active lipolysis
By activating the hormone sensitive lipase by phosphorylation
Why is the hormone sensitive lipase have that name ?
Because 6 hormones work on it (5 activate and 1 inhibit)
