Metabolism Of Eicosanoids

Question 1

What is the location of synthesis of eicosanoids

Answer 1

Cytosol and ER of all tissues

Question 2

What is the precursor molecule of eicosonoids

Answer 2

Arachidonic acid

Question 3

Explain the steps of synthesis of eicosanoids

Answer 3

Question 4

Explain why cortisol is the strongest anti inflmattory and anti allergic

Answer 4

If blocks phospholipase A 2 which inhibits anti inflammatory and anti allergic mediators

Question 5

Explain the inhibitions of eicosanoids synthesis

Answer 5

Question 6

What is a disadvantage of blocking COX1 and how to solve it

Answer 6

Question 7

What are the 3 therapeutic effects of eicosanoids

Answer 7

In respiratory system = bronchodilation so can be used for treatment of asthma
In GIT decreases gastric secretion so can be used for the treatment of gastritis and gastric ulcer
In smooth muscle,especially of the uterus = increases contraction so can be used for induction of delivery

Question 8

List all the clinical applications of eicosanoids

Answer 8