Red Ulcerated Lesions

Question 1

What is epidermolysis bullosa? Characteristics?

Answer 1

Congenital defect in the attachement of the epithelial cells.

• Vesicles and bullae due to minor trauma.
• There is a spectrum of this disease.

Question 2

What are the characteristics of viral diseases?

Answer 2

• Acute onset
• Lymphadenopathy
• Multiple ulcers
• All have vesicle stage

Question 3

What is the steps of herpes simplex?

Answer 3

1. Primary infeciton
2. Latency: Virus takes up by nerves.
3. Recurrent: Effects epi supplied by sensory ganglion.

Question 4

What are the characteristics of primary herpetic gingivostomatitis?

Answer 4

• Lymphadenopathy present

- Numerous pihead vesicles and ulcers in oral cavity on keratinized AND non-keratinized (BOTH).

Question 5

What are the characteristics of recurrent herpes simplex?

Answer 5

• Prodrome: tingling or burning sensation.
• Vesicles and ulcers in small clusters ONLY on Keratinized tissue.
• Recur in same location each time
• Lymphadenopathy not present.

Question 6

What is herpetic whitlow, Herpes gladatorium, Herpes babrae,

Answer 6

W:Herpes simplex on the finger.
G: Herpes common in wrestlers or rugby players.
B: herpes in the beard area due to razor cuts.

Question 7

What is Varicella (chickenpox) and what causes it?

Answer 7

Successive crops of puritic papules, vesicles, ulcers on the skin.
-Caused by Varicella-Zoster HHV-3.

Question 8

What is herpes zoster (Shingles)? What kind of distribution? What can occur as a lingering effect?

Answer 8

Recurrence of HHV-3

• Unilateral Distribution.
• Post-herpetic neuralgia: Chronic severe nerve pain.

Question 9

What is infectious mononucleosis? Caused by? Associated with? Oral mucosa findings?

Answer 9

• Epstein-barr virus by HHV-4.
• Associated with: Burkitt’s lymphoma, Nasopharyngeal carcinoma, Hairy leukoplakia.
• Erythematous, petichiae, ulcers without vesicles.
• Cervical lymphadenopathy

Question 10

What is hand, foot, and mouth disease? Caused by? Characteristic lesions?

Answer 10

• Coxsackievirus, group A
• Vesicles and lesions in oral cavity, with macules and vesicles on hands and feet.
• Flu like symptoms

Question 11

What is Herpangina? Caused by? Locations in mouth?

Answer 11

• Similar to HFM but confined to posterior oral cavity.
• Caused by coxsackievirus group A.
• Soft palate, uvula, tonsillar pillar. ONLY NON-KERATINIZED

Question 12

What is Measels (Rubeola) caused by? Characteristics?

Answer 12

viral infection caused by Paramyxovirus.

• Koplik’s spots
• Mycosal erythema
• small blue-white macules that look like grains of salt.

Question 13

What are the characteristics of autoimmune diseases?

Answer 13

• Gradual onset
• Progressive
• Controlled with corticosteroids.

Question 14

What is the cause of erosive lichen planus? Oral lesion characteristics?

Answer 14

• Immune abnormality involving T lymphocytes.
• White striae along periphery
• Vesicles are rare
• Bilateral

Question 15

What is pemphigus vulgaris? Characteristics? Present under microscope? Treatment?

Answer 15

Autoantibodies attack desmosomes.

• Blisters rupture easily
• Multifocal
• Nikolsky sign sometimes present.
• Tzanck cells present.

Treat with corticosteroids.

Question 16

What is mucous membrane pemphigoid? Characteristics?

Answer 16

Antibodies against basal lamina hemidesmosomes.

• Can cause eye lesions.
• Generalized vesicles and painful ulcers.

Question 17

What is bullous pemphgioid? Characteristics?

Answer 17

same as MMP, but more limited and no scaring.

-Most common auto-immune blistering condition.

Question 18

What is systemic lupus erythematosus?

Answer 18

-Multisystem autoimmune disease with increased B lymphocyte activity and abnormal T cell function.

Question 19

What is chronic cutaneous lupus erythematosus? can cause?

Answer 19

Autoimmune disease, limited to skin and mucosal surfaces.

-Can cause scarring and pigmentation

Question 20

What are some additional characteristics of lupus?

Answer 20

• Kidney failure
• Butterfly rash
• Cardiac involvement
• Gingival lesions.

Question 21

What is riga-fede disease?

Answer 21

-dramatic ulcer on infants with neonatal teeth.

Question 22

What is chronic erythematous candidosis?

Answer 22

-Chronic candida due to denture wearing.

Question 23

What is angular cheilitis?

Answer 23

Saliva pools at corner of the mouth and fungus and bacteria cause infection there.

Question 24

What is candida median rhomboid glossitis?

Answer 24

a posterior lesion on the tongue caused by candida.

Question 25

What are some of the things that cause deep fungal infections? What do they resemble?

Answer 25

1. Histoplasmosis
2. Blastomycosis
3. Paracoccidioidomycosis
4. Coccidioidomycosis
5. Zygomycosis

Resembles sqaumous cell carcinoma.

Question 26

What can congenital syphilis cause?

Answer 26

Hutchingsons incisors and mulberry molars.

Question 27

What are aphthous ulcers? Characteristics? classic appearance?

Answer 27

T-cell mediated immunologic reaction that causes ulcers.

• Non-keratinized mucosa
• White pseudomembranous membrane surrounded by red halo.

Question 28

What is herpetiform apthous ulceration?

Answer 28

-Looks like possible herpes with many small lesions that may coalesce.

Question 29

What is Behcet’s syndrome?

Answer 29

Serious multisystem disease with aphthous like ulcers, genital ulcers, ocular inflammation, skin pustules.

Question 30

What is Erythema Multiforme? Characteristics?

Answer 30

Blistering ulcerative mucocutaneous condition of unknown cause.

• Acute onset
• Target lesions
• Painful ulcers.

Question 31

What is Stevens-johnson syndrome?

Answer 31

Erythema multiforme with oral, skin and ocular or genital lesions.

Question 32

What is Granulomatosis with polyangitis? What does it look like on gums?

Answer 32

• Granulomatous lesions with systemic vasculitis.

- Looks like strawberry gums.

Question 33

What is erythroplasia? Could be what of 3 things?

Answer 33

Catch all term for a persistent, red lesion.

• Dysplasia
• Carcinoma-in-situ
• Superficial squamous cell carcinoma