Red Cell Metabolism Flashcards
True or False, RBC’s have mitochondria
False, they don’t
What mitochondrial process obtains energy in the form of ATP
Anaerobic Glycolysis
What pathway provides ATP for erythrocytes
Embden- Meyerhof (glycolytic) pathway
What are the end products of the Embden- Meyerhof (glycolytic) pathway
Pyruvate/lactate
What is made in the Embden-Meyerhof (glycolytic) pathway to reduce dead met Hb to functionally active reduced haemoglobin
NADH
What is the iron state of dead MetHb
Fe3+
What binds to Hb to decrease its affinity to oxygen, making it available to the tissues
2,3 DPG (diphosphoglyceric Acid )
What are the 3 mechanisms involved in red cell metabolism
Embden-Meyerhof pathway
Hexose/Monophosphate shunt
Rapoport-Luebering Shunt
What are the functions of ATP on RBC membrane
Maintenance of cell shape and deformability
Phosphorylation of sugars
Maintenance of ATPase pumps
In the Hexose- Monophosphate shunt, what product provides a reducing power
NADPH
NADPH provides a reducing power link with ________ for the elimination of peroxide
Glutathione
The hexose-Monophosphate provides protection of _______ groups on the cell membrane and in Hb molecule from oxidation
sulphydril (-SH)
What is used to protect cells oxidant stress
G6PD
Glucose 6-phosphate dehrogenase
The deficiency of glucose-6-phosphate dehydrogenase results in
Haemolysis on exposure to oxidant stress ( drugs)
Deficiency of G6PD is as a result of what type of disease
Sex-linked
A deficiency of G6PD will cause a deficiency of _________, which will result in patients being able to generate adequate ATP
Pyruvate Kinase
True or False, patients with G6PD are usually asymptomatic
True
What are common triggers for persons with G6PD
Antimalarials, analgesics, favs beans, infections
What negative feedback mechanism for occurs due to pyruvate kinase deficiency
An increase in 2,3 DPG due to RBCs haemolysing easily, allowing oxygen to be released more easily
