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Basic Haemotology (1204) > Red Cell Metabolism > Flashcards

Red Cell Metabolism Flashcards

1
Q

True or False, RBC’s have mitochondria

A

False, they don’t

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2
Q

What mitochondrial process obtains energy in the form of ATP

A

Anaerobic Glycolysis

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3
Q

What pathway provides ATP for erythrocytes

A

Embden- Meyerhof (glycolytic) pathway

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4
Q

What are the end products of the Embden- Meyerhof (glycolytic) pathway

A

Pyruvate/lactate

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5
Q

What is made in the Embden-Meyerhof (glycolytic) pathway to reduce dead met Hb to functionally active reduced haemoglobin

A

NADH

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6
Q

What is the iron state of dead MetHb

A

Fe3+

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7
Q

What binds to Hb to decrease its affinity to oxygen, making it available to the tissues

A

2,3 DPG (diphosphoglyceric Acid )

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8
Q

What are the 3 mechanisms involved in red cell metabolism

A

Embden-Meyerhof pathway
Hexose/Monophosphate shunt
Rapoport-Luebering Shunt

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9
Q

What are the functions of ATP on RBC membrane

A

Maintenance of cell shape and deformability
Phosphorylation of sugars
Maintenance of ATPase pumps

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10
Q

In the Hexose- Monophosphate shunt, what product provides a reducing power

A

NADPH

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11
Q

NADPH provides a reducing power link with ________ for the elimination of peroxide

A

Glutathione

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12
Q

The hexose-Monophosphate provides protection of _______ groups on the cell membrane and in Hb molecule from oxidation

A

sulphydril (-SH)

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13
Q

What is used to protect cells oxidant stress

A

G6PD

Glucose 6-phosphate dehrogenase

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14
Q

The deficiency of glucose-6-phosphate dehydrogenase results in

A

Haemolysis on exposure to oxidant stress ( drugs)

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15
Q

Deficiency of G6PD is as a result of what type of disease

A

Sex-linked

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16
Q

A deficiency of G6PD will cause a deficiency of _________, which will result in patients being able to generate adequate ATP

A

Pyruvate Kinase

17
Q

True or False, patients with G6PD are usually asymptomatic

A

True

18
Q

What are common triggers for persons with G6PD

A

Antimalarials, analgesics, favs beans, infections

19
Q

What negative feedback mechanism for occurs due to pyruvate kinase deficiency

A

An increase in 2,3 DPG due to RBCs haemolysing easily, allowing oxygen to be released more easily

Basic Haemotology (1204) (16 decks)

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