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Basic Haemotology (1204) > Leucopoiesis & Growth Factors > Flashcards

Leucopoiesis & Growth Factors Flashcards

1
Q

Site of Leukogenesis

A

Bone marrow (extravascular)

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2
Q

The ratio of myeloid to erythoids in bone marrow

A

3:1 / 15:1

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3
Q

Life span of granulocytes

A

4-8 hours

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4
Q

Life span of lymphocytes

A

several weeks or months

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5
Q

Life span of monocytes

A

10-20 hours

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6
Q

How long does it take for leukocytes to mature

A

10-14 days

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7
Q

What leukocyte has the highest count in the body

A

Neutrophils

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8
Q

What leukocyte has the lowest count in the body

A

Basophils

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9
Q

Term given to a decreased formation of myeloid cells

A

Pancytopenia

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10
Q

Term given to an increase in non-functional, undifferentiated WBC

A

Leukemia

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11
Q

Physical characteristics of monocyte

A

Kidney- Shaped/ Horse- Shaped

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12
Q

Monocytes enter tissues to form….

A

Macrophages

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13
Q

Physical characteristics of Basophils

A

S- Shaped

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14
Q

Basophils move into tissue to form….

A

Mast Cells

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15
Q

What White Blood cell constitutes the bodies first line of defense.

A

Neutrophils

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16
Q

What are eosinophils used for

A

Parasitic infections and Allergic reactions

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17
Q

What WBC is used in muscle repairs

A

Neutrophils

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18
Q

What is the name of the common progenitor cell

A

CFU-GM

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19
Q

What 4 characteristics develop as the cells reach maturity

A

Chemotaxis (membrane receptors)
Phagocytosis (Contractile protein tubulin)
Lysis (lysosomal enzymes)

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20
Q

What is the exception for when surface antigens also called Human leukocyte associated antigens are identical

A

In identical twins

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21
Q

What causes physiologic leucopoiesis to occur ?

A

After exercise and adrenaline injection

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22
Q

What Growth Factors facilitate the production of macrophages

A

M-CSF, GM-CSF, IL-3

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23
Q

What growth factor facilitates the production of Neutrophils, Eosinophils and Basophils from Macrophages and Fibroblasts

A

G-CSF

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24
Q

What Growth factors facilitate the production of Neutrophils and Macrophages from T-Cells and Epidermal Cells

A

IL-3

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25
Q

What is the Maturation Sequence for Leucopoiesis

A

Myeloblast
Promyelocyte
Basophilic/ Neutrophilic/ Eosinophilic Myelocyte,
Basophilic/ Neutrophilic/ Eosinophilic Metamyelocyte
Basophilic/ Neutrophilic/ Eosinophilic band
Basophilic/ Neutrophilic/ Eosinophilic segmented

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26
Q

How many WBCs are usually formed

A

5,000-10,000

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27
Q

True or False WBCs, spend only a few hours in the blood stream before migrating to connective tissue

A

True

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28
Q

True or False, WBCs retain their organelles for protein synthesis

A

True

29
Q

True or False, All WBCs have lysosomes called nonspecific (azurophillic) granules that are conspicuous, therefore very evident in cytoplasm

A

False, the cytoplasm is clear

30
Q

What is the life span for granulocytes in tissues where they are needed

A

4-5 days

31
Q

What are the pluripotent Stem Cells for WBCs

A

Myeblasts, Monoblasts, Lymphoblasts

32
Q

What part of the body stores and releases granulocytes and monocytes

A

Red bone marrow

33
Q

Granulocytes leave the bloodstream in _______ hours and live for _____ days longer

A

8 hours, 5 days

34
Q

Monocytes leave the bloodstream in _______ hours and transform into _____ and live for _______

A

20 hours, Macrophages, several years

35
Q

True or False, Lymphocytes as continuously recycled from blood to tissue fluid to lump and back to blood

A

True

36
Q

What disease causes a decrease formation of all myeloid cell lines

A

Aplastic Anaemia (Pancytopenia)

37
Q

What causes factors causes Pancytopenia

A

Drugs, high radiation, abnormal immune response, idiopathic

38
Q

What disease occurs when there is an increased number of functional, nondifferented white blood cells

A

Leukemia

39
Q

What are the 3 types of Myeloid stem cells

A

Granulocytes, Thrombocytes, Monocytes

40
Q

What is the name of the Lymphoid Stem Cells

A

Lymphocytes

41
Q

True or False, the GM-CSF stimulates cytotoxic and phagocyte activity against bacteria and parasites

A

True

42
Q

What growth factors are produced by fibroblasts, strongly Cells, T-Lymphocytes and endothelial Cells

A

GM-CSF

43
Q

What cells are stimulated by GM-CSF

A

Granulocytes, Monocytes and Erythrocytes

44
Q

What Growth factor stimulate the proliferation and maturation of granulocyte precursors

A

G-CSF

45
Q

What Growth factors are produced by Stromal Cells, Monocytes, Macrophages and endothelial Cells

A

G-CSF

46
Q

What growth hormone is secreted by stromal cells, Macrophages and fibroblasts

A

M-CSF

47
Q

What growth factor is a heavily glycosylated glycoproteins

A

M-CSF

48
Q

What growth factor has a low molecular weight Glycoprotein

A

G-CSF

49
Q

What growth factor is a potent stimulator of macrophage function and activation

A

M-CSF

50
Q

What growth factor increases the expression of MHC II antigen on Macrophages

A

M-CSF

51
Q

What is the second highest leukocyte count

A

Lymphocytes

52
Q

What WBC has a leukocyte count of 5.3%, 2.3%, 0.4%

A

Monocytes, Eosinophils, Basophils

53
Q

What WBC has 3-5 lobes

A

Neutrophils

54
Q

What WBC has the ability for chemotaxis and phagocytosis

A

Neutrophils

55
Q

What WBC has a bi-lobed nucleus

A

Eosinophils

56
Q

What WBC has coarse granules containing lysosomal enzymes and major basic protein

A

Eosinophils

57
Q

What WBC increases parasitic in parasitic infestations and allergic conditions

A

Eosinophils

58
Q

What WBC has a S shaped nucleus

A

Basophils

59
Q

What WBC has granules containing histamine and heparin

A

Basophils

60
Q

What WBC has membrane receptors for lgE

A

Basophils

61
Q

What WBC has a round nucleus with no visible nucleoli, and gets larger with a visible nucleoli when metabolically active

A

Lymphocytes

62
Q

What WBC has a powerful phagocytic action

A

Monocytes

63
Q

Where are Kupffer Cells located

A

Liver

64
Q

What WBC are elevated in Whooping Cough

A

Lymphocytes

65
Q

What WBC is elevated in Typhoid fever , MalariaC Tuberculosis

A

Monocytes

66
Q

What cells are elevated in bacterial infections

A

Neutrophils

67
Q

What WBC is associated with AIDS

A

Too few helper T cells (lymphocytes)

68
Q

What WBC is associated with mononucleosis

A

Lymphocytes

Basic Haemotology (1204) (16 decks)

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