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Basic Haemotology (1204) > Leucopoiesis & Growth Factors > Flashcards

Leucopoiesis & Growth Factors Flashcards

1
Q

Site of Leukogenesis

A

Bone marrow (extravascular)

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2
Q

The ratio of myeloid to erythoids in bone marrow

A

3:1 / 15:1

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3
Q

Life span of granulocytes

A

4-8 hours

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4
Q

Life span of lymphocytes

A

several weeks or months

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5
Q

Life span of monocytes

A

10-20 hours

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6
Q

How long does it take for leukocytes to mature

A

10-14 days

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7
Q

What leukocyte has the highest count in the body

A

Neutrophils

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8
Q

What leukocyte has the lowest count in the body

A

Basophils

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9
Q

Term given to a decreased formation of myeloid cells

A

Pancytopenia

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10
Q

Term given to an increase in non-functional, undifferentiated WBC

A

Leukemia

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11
Q

Physical characteristics of monocyte

A

Kidney- Shaped/ Horse- Shaped

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12
Q

Monocytes enter tissues to form….

A

Macrophages

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13
Q

Physical characteristics of Basophils

A

S- Shaped

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14
Q

Basophils move into tissue to form….

A

Mast Cells

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15
Q

What White Blood cell constitutes the bodies first line of defense.

A

Neutrophils

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16
Q

What are eosinophils used for

A

Parasitic infections and Allergic reactions

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17
Q

What WBC is used in muscle repairs

A

Neutrophils

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18
Q

What is the name of the common progenitor cell

A

CFU-GM

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19
Q

What 4 characteristics develop as the cells reach maturity

A

Chemotaxis (membrane receptors)
Phagocytosis (Contractile protein tubulin)
Lysis (lysosomal enzymes)

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20
Q

What is the exception for when surface antigens also called Human leukocyte associated antigens are identical

A

In identical twins

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21
Q

What causes physiologic leucopoiesis to occur ?

A

After exercise and adrenaline injection

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22
Q

What Growth Factors facilitate the production of macrophages

A

M-CSF, GM-CSF, IL-3

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23
Q

What growth factor facilitates the production of Neutrophils, Eosinophils and Basophils from Macrophages and Fibroblasts

A

G-CSF

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24
Q

What Growth factors facilitate the production of Neutrophils and Macrophages from T-Cells and Epidermal Cells

A

IL-3

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25
What is the Maturation Sequence for Leucopoiesis
Myeloblast Promyelocyte Basophilic/ Neutrophilic/ Eosinophilic Myelocyte, Basophilic/ Neutrophilic/ Eosinophilic Metamyelocyte Basophilic/ Neutrophilic/ Eosinophilic band Basophilic/ Neutrophilic/ Eosinophilic segmented
26
How many WBCs are usually formed
5,000-10,000
27
True or False WBCs, spend only a few hours in the blood stream before migrating to connective tissue
True
28
True or False, WBCs retain their organelles for protein synthesis
True
29
True or False, All WBCs have lysosomes called nonspecific (azurophillic) granules that are conspicuous, therefore very evident in cytoplasm
False, the cytoplasm is clear
30
What is the life span for granulocytes in tissues where they are needed
4-5 days
31
What are the pluripotent Stem Cells for WBCs
Myeblasts, Monoblasts, Lymphoblasts
32
What part of the body stores and releases granulocytes and monocytes
Red bone marrow
33
Granulocytes leave the bloodstream in _______ hours and live for _____ days longer
8 hours, 5 days
34
Monocytes leave the bloodstream in _______ hours and transform into _____ and live for _______
20 hours, Macrophages, several years
35
True or False, Lymphocytes as continuously recycled from blood to tissue fluid to lump and back to blood
True
36
What disease causes a decrease formation of all myeloid cell lines
Aplastic Anaemia (Pancytopenia)
37
What causes factors causes Pancytopenia
Drugs, high radiation, abnormal immune response, idiopathic
38
What disease occurs when there is an increased number of functional, nondifferented white blood cells
Leukemia
39
What are the 3 types of Myeloid stem cells
Granulocytes, Thrombocytes, Monocytes
40
What is the name of the Lymphoid Stem Cells
Lymphocytes
41
True or False, the GM-CSF stimulates cytotoxic and phagocyte activity against bacteria and parasites
True
42
What growth factors are produced by fibroblasts, strongly Cells, T-Lymphocytes and endothelial Cells
GM-CSF
43
What cells are stimulated by GM-CSF
Granulocytes, Monocytes and Erythrocytes
44
What Growth factor stimulate the proliferation and maturation of granulocyte precursors
G-CSF
45
What Growth factors are produced by Stromal Cells, Monocytes, Macrophages and endothelial Cells
G-CSF
46
What growth hormone is secreted by stromal cells, Macrophages and fibroblasts
M-CSF
47
What growth factor is a heavily glycosylated glycoproteins
M-CSF
48
What growth factor has a low molecular weight Glycoprotein
G-CSF
49
What growth factor is a potent stimulator of macrophage function and activation
M-CSF
50
What growth factor increases the expression of MHC II antigen on Macrophages
M-CSF
51
What is the second highest leukocyte count
Lymphocytes
52
What WBC has a leukocyte count of 5.3%, 2.3%, 0.4%
Monocytes, Eosinophils, Basophils
53
What WBC has 3-5 lobes
Neutrophils
54
What WBC has the ability for chemotaxis and phagocytosis
Neutrophils
55
What WBC has a bi-lobed nucleus
Eosinophils
56
What WBC has coarse granules containing lysosomal enzymes and major basic protein
Eosinophils
57
What WBC increases parasitic in parasitic infestations and allergic conditions
Eosinophils
58
What WBC has a S shaped nucleus
Basophils
59
What WBC has granules containing histamine and heparin
Basophils
60
What WBC has membrane receptors for lgE
Basophils
61
What WBC has a round nucleus with no visible nucleoli, and gets larger with a visible nucleoli when metabolically active
Lymphocytes
62
What WBC has a powerful phagocytic action
Monocytes
63
Where are Kupffer Cells located
Liver
64
What WBC are elevated in Whooping Cough
Lymphocytes
65
What WBC is elevated in Typhoid fever , MalariaC Tuberculosis
Monocytes
66
What cells are elevated in bacterial infections
Neutrophils
67
What WBC is associated with AIDS
Too few helper T cells (lymphocytes)
68
What WBC is associated with mononucleosis
Lymphocytes

Basic Haemotology (1204) (16 decks)

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