Red Cell Disorders 2 Flashcards

1
Q

How can the hemoglobin be classified?

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2
Q

What is sickle cell disease ?

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3
Q

What are the types of sickle cell?

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4
Q

Discuss the pathogenesis of sickle cell disease

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5
Q

Discuss the peripheral blood smear for sickle cell disease

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6
Q

What factors affect sickling in sickle cell disease?

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7
Q

What are the clinical features of sickle cell disease ?

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8
Q

What are the symptoms of sickle cell trait?

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9
Q

What symptoms are associated with sickle cell disease?

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10
Q

What usually precipitates Sickle cell crises?

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11
Q

What’s the vaso-occlusive/painful crises?

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12
Q

What’s a sequestration crises in a sickle cell disorder?

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13
Q

What is aplastic crises for sickle cell crises?

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14
Q

What’s hemolytic crises of sickle cell disease?

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15
Q

What is a sickle cell disease diagnose based on?

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16
Q

What are the diagnosis of sickle cell disease?

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17
Q

How do we treat sickle cell disease?

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18
Q

What’s the clinical outcome of homozygous sickle cell disease?

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19
Q

What are thalassemia syndromes?

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20
Q

What is B-thalassemia?

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21
Q

What are the clinical syndromes of B-thalassemia?

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22
Q

What is B-thalassemia major?

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23
Q

What is the pathogenesis of B-thalassemia?

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24
Q

What are the clinicopathogenesis of B-thalassemia major?

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25
Q

What’s the diagnosis of B-thalassemia based on?

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26
Q

What’s the lab findings of Hb electrophoresis of B-thalassemia major?

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27
Q

What is B-thalassemia minor?

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28
Q

Describe B-thalassemia clinical course & treatment

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29
Q

What is alpha-thalassemia?

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30
Q

What is a-thalassemia minima?

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31
Q

What is a-thalassemia minor?

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32
Q

Contrast hemoglobin H and hemoglobin Barts

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33
Q

What are the clinical features of a-thalassemia minima?

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34
Q

What are the clinical features of a-thalassemia minor?

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35
Q

What are the clinical features of Hemoglobin H ?

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36
Q

What are the clinical features of hemoglobin Barts?

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37
Q

What is Paroxysmal Nocturnal Heamoglobinuria?

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38
Q

Describe the pathogenesis of Paroxysmal Nocturnal Hemoglobinuria

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39
Q

What are the clinical features of Paroxysmal Nocturnal Hemoglobinuria ?

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40
Q

How can we diagnose paroxysmal nocturnal Hemoglobinuria?

A
41
Q

What are the associated conditions of paroxysmal nocturnal Hemoglobinuria?

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42
Q

Is thalassemia intra or extravascular?

A

Extravascular