Antimycobacterial Drugs Flashcards by Jhaunte Braithwaite

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What are the general characteristics of mycobacteria?

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Describe the microbiology 9f tuberculosis

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How can we classify resistance of TB?

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Contrast latent & active infection

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What does a TST/PPD test look like?

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Which patients do we treat latent TB ?

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What are the goals of TB therapy?

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What are the principles of therapy for tuberculosis?

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What is direct observed tuberculosis therapy?

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What drugs are us3ed for tuberculosis treatment?

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What are the first line drugs of tuberculosis?

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Q

What are the generalities of Rifamycins?

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What is the mechanism of action & resistance to Rifampin?

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What are the pharmacokinetics of Rifampin?

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What is the antimicrobial spectrum of Rifampin?

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What are the clinical applications of Rifampin ?

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What are the adverse effects of Rifampin?

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What are the properties of rifabutin?

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What does Rifampin do to CYP?

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What are the generalities of isoniazid?

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What is the antimicrobial spectrum of isoniazid?

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What are the mechanisms of action & resistance of isoniazid?

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What occurs in mycolic acid synthesis ?

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Illustrate MOA of isoniazid

Describe the MOR of isoniazid

What are the isoniazid pharmacokinetics?

What are the adverse effects of isoniazid?

What are the generalities & antimicrobial spectrum of pyrazinamide?

What is the MOA & MOR of pyrazinamide?

What are the pharmacokinetics of pyrazinamide?

What are the adverse effects of pyrazinamide?

Which antimycobacterials lead to hepatotoxicity?

What are the generalities of ethambutol?

What is the MOA & MOR of ethambutol?

What is the pharmacokinetics of ethambutol?

What are the adverse effects of ethambutol?

What are the 2nd line drugs for tuberculosis?

What is the MOA & clinical use of streptomycin?

What are the adverse effects of streptomycin?

What are the MOA & Adverse effects of ethionamide?

What are the MOA of Amikacin?

What are the adverse effects of Amikacin?

What are the MOA & adverse effects of levofloxacin?

What is the duration of treatment of latent tuberculosis?

What’s the duration of treatment of active pulmonary tuberculosis?

What’s the phases of extrapulmonary tuberculosis?

What are the minor adverse effects of managing drugs?

What are major adverse drug effects of TB treatment?

What is leprosy?

What are the drugs of leprosy?

What are the MOA, clinical use & PK of dapsone?

What are the adverse effects of dapsone?

What does erythema Nodosa leprosum look like?

What is the MOA and clinical use of clofazimine?

What are the AE of clofazimine?

What is the WHO recommendation for leprosy?

What’s the major difference if Rifampin and rifabutin?

Is isoniazid safe in pregnancy?

Is pyrazinamide safe in pregnancy?

Is ethambutol safe in pregnancy?