Antimycobacterial Drugs Flashcards by Jhaunte Braithwaite

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What are the general characteristics of mycobacteria?

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Describe the microbiology 9f tuberculosis

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How can we classify resistance of TB?

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Contrast latent & active infection

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What does a TST/PPD test look like?

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Which patients do we treat latent TB ?

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What are the goals of TB therapy?

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What are the principles of therapy for tuberculosis?

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What is direct observed tuberculosis therapy?

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What drugs are us3ed for tuberculosis treatment?

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What are the first line drugs of tuberculosis?

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What are the generalities of Rifamycins?

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What is the mechanism of action & resistance to Rifampin?

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What are the pharmacokinetics of Rifampin?

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What is the antimicrobial spectrum of Rifampin?

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What are the clinical applications of Rifampin ?

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What are the adverse effects of Rifampin?

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What are the properties of rifabutin?

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What does Rifampin do to CYP?

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What are the generalities of isoniazid?

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What is the antimicrobial spectrum of isoniazid?

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What are the mechanisms of action & resistance of isoniazid?

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Q

What occurs in mycolic acid synthesis ?

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Q

Illustrate MOA of isoniazid

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Describe the MOR of isoniazid

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What are the isoniazid pharmacokinetics?

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What are the adverse effects of isoniazid?

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What are the generalities & antimicrobial spectrum of pyrazinamide?

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What is the MOA & MOR of pyrazinamide?

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What are the pharmacokinetics of pyrazinamide?

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What are the adverse effects of pyrazinamide?

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Which antimycobacterials lead to hepatotoxicity?

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What are the generalities of ethambutol?

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What is the MOA & MOR of ethambutol?

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What is the pharmacokinetics of ethambutol?

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What are the adverse effects of ethambutol?

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What are the 2nd line drugs for tuberculosis?

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What is the MOA & clinical use of streptomycin?

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What are the adverse effects of streptomycin?

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What are the MOA & Adverse effects of ethionamide?

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What are the MOA of Amikacin?

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What are the adverse effects of Amikacin?

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What are the MOA & adverse effects of levofloxacin?

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What is the duration of treatment of latent tuberculosis?

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What’s the duration of treatment of active pulmonary tuberculosis?

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What’s the phases of extrapulmonary tuberculosis?

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What are the minor adverse effects of managing drugs?

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What are major adverse drug effects of TB treatment?

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What is leprosy?

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What are the drugs of leprosy?

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What are the MOA, clinical use & PK of dapsone?

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What are the adverse effects of dapsone?

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What does erythema Nodosa leprosum look like?

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What is the MOA and clinical use of clofazimine?

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What are the AE of clofazimine?

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What is the WHO recommendation for leprosy?

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What’s the major difference if Rifampin and rifabutin?

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Is isoniazid safe in pregnancy?

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Is pyrazinamide safe in pregnancy?

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Is ethambutol safe in pregnancy?

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