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RHS > Antimycobacterial Drugs > Flashcards

Antimycobacterial Drugs Flashcards

1
Q

Remember this

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2
Q

What are the general characteristics of mycobacteria?

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3
Q

Describe the microbiology 9f tuberculosis

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4
Q

How can we classify resistance of TB?

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5
Q

Contrast latent & active infection

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6
Q

What does a TST/PPD test look like?

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7
Q

Which patients do we treat latent TB ?

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8
Q

What are the goals of TB therapy?

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9
Q

What are the principles of therapy for tuberculosis?

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10
Q

What is direct observed tuberculosis therapy?

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11
Q

What drugs are us3ed for tuberculosis treatment?

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12
Q

What are the first line drugs of tuberculosis?

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13
Q

What are the generalities of Rifamycins?

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14
Q

What is the mechanism of action & resistance to Rifampin?

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15
Q

What are the pharmacokinetics of Rifampin?

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16
Q

What is the antimicrobial spectrum of Rifampin?

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17
Q

What are the clinical applications of Rifampin ?

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18
Q

What are the adverse effects of Rifampin?

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19
Q

What are the properties of rifabutin?

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20
Q

What does Rifampin do to CYP?

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21
Q

What are the generalities of isoniazid?

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22
Q

What is the antimicrobial spectrum of isoniazid?

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23
Q

What are the mechanisms of action & resistance of isoniazid?

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24
Q

What occurs in mycolic acid synthesis ?

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25
Q

Illustrate MOA of isoniazid

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26
Q

Describe the MOR of isoniazid

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27
Q

What are the isoniazid pharmacokinetics?

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28
Q

What are the adverse effects of isoniazid?

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29
Q

What are the generalities & antimicrobial spectrum of pyrazinamide?

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30
Q

What is the MOA & MOR of pyrazinamide?

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31
Q

What are the pharmacokinetics of pyrazinamide?

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32
Q

What are the adverse effects of pyrazinamide?

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33
Q

Which antimycobacterials lead to hepatotoxicity?

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34
Q

What are the generalities of ethambutol?

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35
Q

What is the MOA & MOR of ethambutol?

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36
Q

What is the pharmacokinetics of ethambutol?

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37
Q

What are the adverse effects of ethambutol?

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38
Q

What are the 2nd line drugs for tuberculosis?

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39
Q

What is the MOA & clinical use of streptomycin?

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40
Q

What are the adverse effects of streptomycin?

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41
Q

What are the MOA & Adverse effects of ethionamide?

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42
Q

What are the MOA of Amikacin?

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43
Q

What are the adverse effects of Amikacin?

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44
Q

What are the MOA & adverse effects of levofloxacin?

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45
Q

What is the duration of treatment of latent tuberculosis?

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46
Q

What’s the duration of treatment of active pulmonary tuberculosis?

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47
Q

What’s the phases of extrapulmonary tuberculosis?

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48
Q

What are the minor adverse effects of managing drugs?

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49
Q

What are major adverse drug effects of TB treatment?

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50
Q

What is leprosy?

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51
Q

What are the drugs of leprosy?

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52
Q

What are the MOA, clinical use & PK of dapsone?

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53
Q

What are the adverse effects of dapsone?

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54
Q

What does erythema Nodosa leprosum look like?

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55
Q

What is the MOA and clinical use of clofazimine?

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56
Q

What are the AE of clofazimine?

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57
Q

What is the WHO recommendation for leprosy?

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58
Q

What’s the major difference if Rifampin and rifabutin?

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59
Q

Is isoniazid safe in pregnancy?

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60
Q

Is pyrazinamide safe in pregnancy?

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61
Q

Is ethambutol safe in pregnancy?

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RHS (34 decks)

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