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PHAR2005 > Receptor Structure > Flashcards

Receptor Structure Flashcards

1
Q

What are the four families of receptors?

A

Ligand-gated ion channels
G-protein coupled receptors
Kinase-linked and related receptors
Nuclear receptors

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2
Q

What are some examples of LGICs?

A 
nAChRs (ACh)
5-HT3R (5-HT)
GABAAR (GABA)
GlyR (glycine)
Ionotropic GluR (glutamate)
P2X (ATP)
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3
Q

Which neurotransmitters cause excitation via LGICs?

A

ACh
5-HT
Glutamate
ATP

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4
Q

Which neurotransmitters causes inhibition via LGICs?

A

GABA

Glycine

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5
Q

How many transmembrane alpha-helices does a pentameric LGIC have?

A

Four

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6
Q

What are some examples of pentameric LGICs?

A

nAChRs
GABAARs
GlyRs
5-HT3Rs

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7
Q

What is an example of a tetrameric LGIC?

A

Ionotropic GluRs

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8
Q

What is an example of a trimeric LGIC?

A

P2X

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9
Q

All pentameric LGICs have which extracellular structure?

A

Cys-loop

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10
Q

What are the subtypes of GluRs?

A

AMPARs
NMDARs
Kainate receptors

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11
Q

Which subunits undergo a conformational change upon the binding of a ligand to NAChRs?

A

2 alpha-helices lining the pore

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12
Q

What term describes the structure of G-proteins?

A

Heterotrimeric

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13
Q

What are some examples of GPCRs?

A 
Muscarinic AChRs
Metabotropic GluRs
5-HT receptors
GABABRs
Dopamine receptors
Adrenergic receptors
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14
Q

How many alpha-helical transmembrane domains do GPCRs have?

A

Seven

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15
Q

What are the types of kinase-linked and related receptors?

A

Tyrosine kinase receptors
Tyrosine kinase-linked receptors
Serine/threonine kinase receptors
Guanylyl cyclase receptors

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16
Q

What are the two domains of kinase-linked and related receptors?

A

Extracellular ligand-binding domain

Intracellular catalytic domain

17
Q

What are the two domains of intracellular receptors?

A

DNA-binding domain

Ligand-binding domain

18
Q

What are the timescales of the actions of the four receptors types?

A

LGICs - ms
GPCRs - s
Kinase-linked and related receptors - hours
Intracellular receptors - hours/days

PHAR2005 (24 decks)

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