Competitive and Non-Competitive Antagonism Flashcards
1
Q
What is the Gaddum equation?
A
PAR = [A]/KA(1+([B]/KB)+[A])
2
Q
How does an increase in the concentration of a reversible competitive antagonist affect the agonist’s dose-response curve?
A
Parallel shift to right
3
Q
What is the Schild equation?
A
(r-1) = [B]/KB
4
Q
What is the gradient of a Schild plot for a reversible competitive antagonist?
A
~1
5
Q
What does it mean if two antagonists have a similar KB?
A
They have a similar affinity for the receptor
