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PHAR2005 > Amino Acid NTS > Flashcards

Amino Acid NTS Flashcards

1
Q

Which transporter removes glutamate from the synaptic cleft?

A

Excitatory amino acid transporter (EAAT)

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2
Q

Which transporter moves glutamate into vesicles?

A

Vesicular glutamate transporter (VGLUT)

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3
Q

What are the two options of product in glutamate breakdown?

A

Glutamine

Alpha-ketoglutarate

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4
Q

Which enzyme converts glutamate to GABA?

A

Glutamatic acid decarboxylase (GAD)

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5
Q

Which transporter removes GABA from the synaptic cleft?

A

GABA transporter (GAT)

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6
Q

Which transporter moves GABA into vesicles?

A

Vesicular inhibitory amino acid transporter (VIAAT)

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7
Q

Which transporter removes glycine from the synaptic cleft?

A

GlyT-1 and GlyT-2

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8
Q

Which transporter moves glycine into vesicles?

A

Vesicular inhibitory amino acid transporter (VIAAT)

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9
Q

How many transmembrane domains do ionotropic GluR subunits have?

A

3

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10
Q

How many subunits do ionotropic GluRs have?

A

4

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11
Q

Which agonists bind to AMPARs?

A

Glutamate
Kainate
AMPA

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12
Q

Which agonists bind to kainate receptors?

A

Glutamate
Kainate
Domoic acid

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13
Q

Which agonists bind to NMDARs?

A

Glutamate/glycine

NMDA

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14
Q

What are the groups of mGluRs and their effects?

A

I - activate PLC
II - inhibit adenylyl cyclase
III - inhibit adenylyl cyclase

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15
Q

Which ion blocks NMDARs?

A

Mg2+

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16
Q

What is the effect of GABAARs?

A

Cl- influx

17
Q

Name two GABAAR agonists

A

GABA

Muscimol

18
Q

What is the effect of GABABRs?

A

Activate cAMP - increase K+ efflux, decrease Ca2+ influx

19
Q

Name two GABABR agonists

A

GABA

Baclofen

20
Q

How many subunits in a GABAAR?

A

5

21
Q

How many subunits in a GABABR?

A

2

22
Q

What is the effect of post-synaptic GABABRs?

A

Associated K+ channel opens - K+ efflux - hyperpolarisation

23
Q

What is the effect of pre-synaptic GABABRs?

A

Prevents Ca2+ channels from opening - decreases NT release - decreases EPSP magnitude

PHAR2005 (24 decks)

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