receptor regulation

Question 1

constitutively active

Answer 1

stable level of activity

Question 2

4 kinds of known GABA receptor modulators

Answer 2

Benzodiazepine
Barbiturate
Picrotoxin
Ethanol (alcohol)

Question 3

dirty drug

Answer 3

a ligand which has affinity for more than one type of receptor

Question 4

fight or flight response

Answer 4

adrenergic response in dangerous situations

Question 5

therapeutic index

Answer 5

index where we seperate the wanted effects from the unwanted side effects

Question 6

therapeutic index (formula)

Answer 6

therapeutic indec (TI) = TD50/ED50

Question 7

desensitized

Answer 7

not sensitive for the drug, mostly due to overstimulation

Question 8

tachyphylaxis

Answer 8

acute tolerance for a drug.

clockwise hysteresis in the dose-response curve

Question 9

supersensitivity

Answer 9

abnormal exaggerated response to stimulation which occures after a series of administrations

Question 10

inverse agonist

Answer 10

intrinsic efficacy lower than 1. Binds to the receptor and has the opposite effect of what the full agonist does

Question 11

beta-1 receptor

Answer 11

in the heart

binds to adrenalin

Question 12

beta-2 receptor

Answer 12

in the lungs

binds to salbutamol

Question 13

2 reasons why side effects occur

Answer 13

high affinety for multiple receptors

receptor is present in many tissues or organs

Question 14

beta-arrestin signaling

Answer 14

desensitization signal from receptors