Drug action: phamacodynamics

Question 1

phytotherapy

Answer 1

a form of ‘‘kruidengeneeskunde’’

Question 2

agonist

Answer 2

a drug that can activate the receptor

Question 3

antagonist

Answer 3

a drug that binds to a receptor to prevent an agonist from binding

Question 4

ehrlich’s principle

Answer 4

a drug will not act, unless bound

Question 5

3 players in drug action

Answer 5

drug, receptor and endogenous ligand

Question 6

3 important things that bind ligand to binding pocket

Answer 6

size, shape and chemical interactions

Question 7

4 types of chemical interactions

Answer 7

van de waals interactions
ionic bonds
hydrogen bonds
covalent interactions

Question 8

stereo-isomer

Answer 8

mirro-image of a ligand

Question 9

4 forms of proteins

Answer 9

receptors
enzymes
ion channels, transporters and pumps
nucleic acids

Question 10

types of receptors

Answer 10

ion channels
g-protein coupled receptors
kinase receptors
nuclear receptors

Question 11

opium

Answer 11

purified substances from natural products

Question 12

endogenous signaling molecules

Answer 12

hormones
neurotransmitters
immune-mediators
vitamins
metabolites (fatty-acids)

Question 13

receptors proper

Answer 13

targets for endogenous signaling molecules