drug action: binding, agonism and antagonism

Question 1

association

Answer 1

binding

Question 2

dissociation

Answer 2

unbinding

Question 3

residence time

Answer 3

time that a ligand is bound to the binding pocket

Question 4

affinity constant (formule)

Answer 4

Ka= K-1 : K+1

Question 5

affinity

Answer 5

how good binding is and how much a ligand whats to bind to the receptor

Question 6

Ka (affinity constant)

Answer 6

conecentration at half maximal occupation of population

Question 7

occupancy

Answer 7

percentage of receptors that is occupied by a ligand

Question 8

conformation change

Answer 8

change of shape of the receptor

Question 9

intrinsic efficacy

Answer 9

capacity to induce active conformation

Question 10

2 important things that depends the response

Answer 10

number of receptors

intrinsic efficacy

Question 11

EC50

Answer 11

concentration at which we have 50% effect

Question 12

ED50

Answer 12

concentration at which we have 50% effect

Question 13

potency

Answer 13

dose at which effects occur

Question 14

efficacy

Answer 14

magnitude of effect after binding

Question 15

receptor reserve

Answer 15

when you get maximum effect even if not all receptors are occupied