pharmacokinetics

Question 1

pharmacodynamics

Answer 1

what the drug does to the body

Question 2

pharmacokinetics

Answer 2

what the body does to the drug

Question 3

types of oral drugs

Answer 3

enteric coated tablets
capsules
retard (slow release)

Question 4

lipophilic drugs

Answer 4

passing membrane with diffusion

Question 5

hydrophilic drugs

Answer 5

passing membrane with active transport or paracellular transport

Question 6

p glycoprotein (PgP)

Answer 6

active transport of drugs out of the cell

- PgP blocked with verapamil

Question 7

bioavailability

Answer 7

fraction of the drug which will make it into the systemic circulation

Question 8

CYP enymes

Answer 8

metabolize endogenous compounds and foreign compounds in the liver

Question 9

first pass metabolism

Answer 9

pre-systemic metabolism in the liver

Question 10

routes of administration

Answer 10

oral
transdermal
local
rectal
intramuscular
intraocular/ocular
inhalation
subcutaneous

Question 11

formula for concentration

Answer 11

C=D/Vd

Question 12

clearance

Answer 12

rate of drug elimination in the kidney

Question 13

half life

Answer 13

50% of the total concentration at that moment is cleared