glucocorticoids

Question 1

regulation of cortisol secretion

Answer 1

CRH (hypothalamus)–> ACTH (pituitary) –> cortisol (adrenal cortex)

Question 2

addison’s disease

Answer 2

people who do not produce cortisol

Question 3

cushing’s syndrome

Answer 3

people who produce too much cortisol

• adenoma in the pituitary
• adrenal tumor

Question 4

NRC1

Answer 4

glucocorticoid receptor

Question 5

NRC2

Answer 5

mineralocorticoid receptor

Question 6

biased signaling

Answer 6

seperating several pathways coming from receptor type

Question 7

side effects of corticosteroid therapy

Answer 7

osteoporosis
myopathy
GI tract: infections, peptic ulcer, pancreatitis
Endocrine: low metabolism
Eye: cataract, tissue atrophy, intraocular pressure
Cardio: dyslipedemia, hypercoagulability, hypertension
Neuro: psychosis, euphoria
Skin: hyperpigmentation, infection
Immune suppression

Question 8

11b-hydroxysteroid dehydrogenase type 1

Answer 8

cortisone –> cortisol (liver)

Question 9

11b-hydroxysteroid dehydrogenase type 2

Answer 9

cortisol –> cortisone (kidney)

Question 10

glucocorticoid receptor

Answer 10

necessary for anti-inflammatory effects

Question 11

cortisol

Answer 11

binds glucocorticoid receptor and mineralo-corticoid receptor

Question 12

aldosterone

Answer 12

binds mineralo-corticoid receptor

Question 13

pseudo-hyperaldosteronemia

Answer 13

high aldosterone in the blood because of high binding of cortisol to the mineralocortoid receptors

Question 14

dexametasone

Answer 14

high GR affinity and low MR affinity